Decrease of Obesity by Allantoin via Imidazoline I₁-Receptor Activation in High Fat Diet-Fed Mice

Figure 3

The inhibitory effect of allantoin on energy intake in HFD-fed mice. Efaroxan (1.5 mg/kg) was administered 30 min before the intraperitoneal injection of allantoin (5 mg/kg). The value showed the mean ± SEM of eight animals. ^∗∗∗𝑃<0.001 compared with the normal chow-fed group; ^###𝑃<0.001 compared with the vehicle-treated HFD-fed group.