Decrease of Obesity by Allantoin via Imidazoline I₁-Receptor Activation in High Fat Diet-Fed Mice

Table 1

The inhibitory effects of allantoin on adipose tissue (eWAT) weight and ratio in HFD-fed mice. Efaroxan (1.5 mg/kg) was injected 30 min prior to the injection of allantoin (5 mg/kg).

	eWAT (g)	eWAT ratio (%)
Normal mice	0.85 ± 0.02	2.70 ± 0.07
HFD-fed mice
+vehicle	2.04 ± 0.03***	4.00 ± 0.06***
+allantoin	0.89 ± 0.03	2.52 ± 0.06
+efaroxan and allantoin	2.02 ± 0.02***	3.94 ± 0.06***

The values represent the mean ± SEM of eight animals. The eWAT ratio was calculated by dividing the eWAT weight with body weight for each animal and was expressed as a percentage. ***𝑃<0.001 compared with the normal mice.