Evaluation of Oral Subchronic Toxicity of Soshiho-Tang Water Extract: The Traditional Herbal Formula in Rats

Table 5

Hematological values of rats treated orally with SST for 13 weeks.

Parameters	Male				Female
	Control	500 mg/kg	1000 mg/kg	2000 mg/kg	Control	500 mg/kg	1000 mg/kg	2000 mg/kg
WBC (×10^3/𝜇L)	13.50 ± 3.755	11.19 ± 3.405	10.88 ± 2.983	11.46 ± 2.415	8.30 ± 2.100	8.61 ± 2.266	7.93 ± 2.220	8.84 ± 2.155
RBC (×10^6/𝜇L)	9.13 ± 0.353	9.14 ± 0.445	9.38 ± 0.349	9.00 ± 0.265	8.59 ± 0.312	8.43 ± 0.437	8.44 ± 0.383	8.50 ± 0.354
HGB (g/dL)	16.2 ± 0.77	16.4 ± 0.57	16.6 ± 0.64	16.1 ± 0.44	16.0 ± 0.38	16.1 ± 0.57	16.2 ± 0.77	16.3 ± 0.74
HCT (%)	49.1 ± 2.00	50.1 ± 1.62	50.1 ± 2.11	48.6 ± 1.17	48.0 ± 1.55	47.7 ± 1.99	47.5 ± 2.12	48.0 ± 1.91
MCV (fL)	53.8 ± 1.72	54.9 ± 1.98	53.4 ± 1.45	54.1 ± 1.56	55.9 ± 1.31	56.6 ± 1.12	56.3 ± 2.37	56.5 ± 1.91
MCH (pg)	17.7 ± 0.91	18.0 ± 0.84	17.7 ± 0.50	17.9 ± 0.72	18.7 ± 0.53	19.1 ± 0.54	19.2 ± 0.88	19.2 ± 0.74
MCHC (g/dL)	32.9 ± 0.98	32.8 ± 0.56	33.1 ± 0.37	33.1 ± 0.61	33.4 ± 0.75	33.8 ± 0.74	34.1 ± 0.45	34.0 ± 0.84
PLT (×10^3/𝜇L)	1110 ± 84.7	1061 ± 124.4	1038 ± 122.2	1086 ± 94.6	1082 ± 62.3	1072 ± 142.6	1025 ± 108.8	1196 ± 550.6
Reticulocyte (%)	2.5 ± 0.41	2.3 ± 0.33	2.3 ± 0.43	2.3 ± 0.39	2.5 ± 0.42	2.5 ± 0.29	2.1 ± 0.47	2.8 ± 0.98
Neutrophils (%)	15.09 ± 5.508	16.58 ± 5.953	19.51 ± 7.614	17.27 ± 5.569	12.50 ± 4.448	13.24 ± 4.517	11.28 ± 4.780	12.42 ± 4.247
Lymphocytes (%)	79.2 ± 5.78	77.7 ± 5.60	74.8 ± 8.29	76.5 ± 6.17	81.8 ± 4.52	80.7 ± 5.28	82.5 ± 4.97	82.4 ± 4.55
Monocytes (%)	3.2 ± 0.98	3.1 ± 0.66	2.9 ± 1.12	3.3 ± 0.74	2.8 ± 0.69	3.2 ± 0.85	3.2 ± 0.58	2.6 ± 0.64
Eosinophils (%)	1.1 ± 0.28	1.2 ± 0.40	1.4 ± 0.44	1.2 ± 0.29	1.2 ± 0.25	1.3 ± 0.60	1.3 ± 0.32	1.1 ± 0.33
Basophils (%)	0.6 ± 0.22	0.8 ± 0.22	0.7 ± 0.21	0.8 ± 0.23	0.7 ± 0.30	0.6 ± 0.28	0.7 ± 0.28	0.6 ± 0.26
LUC (%)	0.9 ± 0.31	0.8 ± 0.24	0.8 ± 0.22	1.1 ± 0.56	1.0 ± 0.22	1.0 ± 0.27	1.0 ± 0.22	0.8 ± 0.22
PT (sec)	15.9 ± 1.05	16.2 ± 0.71	16.8 ± 1.20	17.2 ± 1.13*	15.5 ± 0.78	15.2 ± 0.53	16.1 ± 1.77	16.2 ± 1.21
APTT (sec)	16.8 ± 1.52	17.1 ± 0.79	17.3 ± 0.82	17.1 ± 0.87	14.6 ± 1.22	14.4 ± 0.99	14.5 ± 1.32	14.3 ± 1.50

∗Significant differences from control group (𝑃<0.05).