The Protective Effect of Alpha-Lipoic Acid in Lipopolysaccharide-Induced Acute Lung Injury Is Mediated by Heme Oxygenase-1

Figure 4

Effects of SnPP on the attenuation of ALA on LPS-induced protein accumulation in BALF and lung wet/dry weight ratio. Rats were intraperitoneally injected with ALA 1 h before or 3 h after intratracheal instillation of LPS (5 mg/kg). In some rats, SnPP was administered 2 h and ALA 1 h before LPS instillation. The protein level in BALF (a) and pulmonary edema determined by the wet/dry weight ratio (b) were measured at 6 h after LPS instillation. Data were presented as means ± SEM (𝑛=5). *𝑃<0.05; **𝑃<0.01 versus LPS-instilled alone group; ^#𝑃<0.05 versus LPS+ALA group.

(a)

(b)