Resveratrol Impedes the Stemness, Epithelial-Mesenchymal Transition, and Metabolic Reprogramming of Cancer Stem Cells in Nasopharyngeal Carcinoma through p53 Activation
Figure 7
Resveratrol suppressed the in vivo growth of CSCs. (a) Mice without resveratrol feeding (w/o RV) were 6 g thinner in body weight as compared with the mice with resveratrol feeding (w/ RV) after 2 weeks. (b) By hypoglossal injection and without resveratrol feeding, the indurate tumor lumps disseminated around NOD/SCID mouse’s buccal mucosa after two weeks. (c) By hypoglossal injection and without resveratrol feeding for two weeks, GFP-lentivirus-infected TW01 CSCs grew throughout the tongue (bottom left) and lower jaw (bottom right) of the mouse, as seen under a Sky-blue II epifluorescent light (tumor size 50–270 mm3). (d) As seen under a Sky-blue II epifluorescent light, TW01 CSCs were eradicated in the hypoglossal region of the mouse tube-fed with resveratrol after two weeks. (**; **).
