Novel Bioactivity of Ellagic Acid in Inhibiting Human Platelet Activation
Inhibitory effects of ellagic acid on p38 MAPK, ERK1/2, JNK1/2, and Akt phosphorylation in collagen-activated platelets. Washed platelets ( cells/mL) were preincubated with 50 and 80 μM ellagic acid or 0.5% DMSO, followed by the addition of 1 μg/mL collagen to trigger platelet activation. The cells were collected, and subcellular extracts were analyzed for (a) p38 MAPK, (b) ERK1/2, (c) JNK1/2, and (d) Akt phosphorylation. The data are presented as the means ± S.E.M. (). *, **, and ***, compared with the control (resting) group; # and ##, compared with the collagen-treated group.
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