Antidiabetic and Hypolipidemic Activities of Curculigo latifolia Fruit:Root Extract in High Fat Fed Diet and Low Dose STZ Induced Diabetic Rats

Table 8

Expression of candidate genes in adipose tissue.

Group	IRS1	IGF	GLUT4	PPARγ	PPARα	AdipoR1	AdipoR2	Leptin	LPL	Lipase	Gapdh
Group 1	1.5371	1.8971	1.4174	1.5781	1.7697	1.6875	1.2268	0.9548	0.5681	0.6158	0.9851
Group 2	0.4879	0.7495	0.5275	0.2414	0.4568	0.5967	0.5692	3.7523*	0.8751	0.7681	0.8562
Group 3	0.4378	0.5644	0.3194	0.2089	0.3699	0.4298	0.4692	0.5689	0.7521	0.5821	1.5240
Group 4	1.3280*	1.7462*	2.0911*	2.9885*	1.5538*	2.8792*	2.1732*	1.5982*	3.5418*	1.5556*	1.4338
Group 5	1.7888*	2.3779*	1.4028*	1.3769*	0.8992*	2.0781*	2.3976*	2.8826*	2.4351*	1.9261*	1.3561
Group 6	1.6971*	2.5811*	1.0247*	1.5571*	1.6982*	2.1169*	3.4691*	2.9871*	2.9984*	2.4861*	1.5983
Group 7	1.1555*	0.7924	1.3333*	1.8634*	0.6282*	1.7295*	1.8059*	1.055	0.8564	0.7539	1.2374

Data are means ± SD for expression of candidate genes in adipose tissue of normal rats (Group 1), obese rats (Group 2), diabetic control rats (Group 3), diabetic rats treated with 50 mg/kg bw of C. latifolia fruit:root extracts (Group 4), diabetic rats treated with 100 mg/kg bw of C. latifolia fruit:root extracts (Group 5), diabetic rats treated with 200 mg/kg bw of C. latifolia fruit:root extracts (Group 6), and diabetic rats treated with 10 mg/kg bw of glibenclamide (Group 7).
*Indicates 𝑃<0.05 compared with diabetic control rats (Group 3).