Amelioration of Cadmium-Produced Teratogenicity and Genotoxicity in Mice Given Arthrospira maxima (Spirulina) Treatment

Table 6

Effect of Arthrospira maxima (AM) on the genotoxicity induced by cadmium (Cd) in pregnant mice and their fetuses.

Treatment (mg/kg)	Pregnant females		Fetuses
	MNPE; Mean ± SEM	MNNE; Mean ± SEM	MNPE; Mean ± SEM	MNNE; Mean ± SEM
Water	1.66±0.516^b	29.33±4.78^b	5.16±0.983^b	31.83±5.13^b
Tween	1.83±0.753^b	28.83±5.20^b	4.33±0.816^b	28.00±7.87^b
AM (800)	2.16±0.753^b	34.00±6.98^b	4.66±0.516^b	29.33±6.32^b
Cd (1.5)	14.16±1.472^a	118.16±11.33^b	14.33±1.366^a	120.50±17.54^a
AM + Cd (200)	8.83±1.169^a,b	106.33±16.02^a,b	9.33±1.033^a,b	108.33±15.31^a,b
AM + Cd (400)	7.83±0.753^a,b	92.16±10.24^a,b	6.83±0.753^a,b	93.00±10.79^a,b
AM + Cd (800)	4.83±0.408^a,b	70.50±14.43^a,b	5.33±0.816^a,b	78.66±9.61^a,b

The determinations were made with 8 pregnant mice per group and in 4 fetuses per group. Micronucleated polychromatic erythrocytes (MNPE) were determined in 1000 polychromatic erythrocytes per mice, and micronucleated normochromatic erythrocytes (MNNE) were determined in 1000 normochromic erythrocytes per mice. Results are shown as the mean ± SEM. ^aStatistically significant difference with respect to the control value and ^bwith respect to the value of Cd treated mice. One-way ANOVA Student Newman Keuls tests; 𝑃<0.05.