612527.fig.004
Figure 4: Inhibitory effects of the nine test compounds on hOAT3-mediated ES uptake. Ten-minute uptake of [3H]ES (1 μM) was measured in HEK-hOAT3 cells in the absence and presence of test compounds (50 μM) or probenecid (1000 μM). Data represent hOAT3-mediated transport specifically, that is, data have been corrected for background ES accumulation measured in empty vector transfected cells. Values are . of triplicate values from a representative experiment. , , and as determined by one-way ANOVA followed by Dunnett’s t-test.