Gallic Acid Induces a Reactive Oxygen Species-Provoked c-Jun NH2-Terminal Kinase-Dependent Apoptosis in Lung Fibroblasts
Figure 6
Schematic model of gallic acid-induced apoptosis pathway in primary cultured murine lung fibroblasts. Incubation of fibroblasts with gallic acid activated ROS-mediated DNA damage signaling pathway by triggering both JNK and ATM-dependent activation of p53. The transcriptional activation of p53 upregulated the proapoptotic molecules, such as PUMA and Fas, consequently leading to apoptotic cell death.
