Review Article

A Systematic Review of the Efficacy of Centella asiatica for Improvement of the Signs and Symptoms of Chronic Venous Insufficiency

Table 2

Outcomes assessed.

StudyOutcome measuresConclusion

Allegra et al., 1981 [38]Pain, heaviness, leg oedema, trophic lesions, easy tiredness, skin hypothermia, varicosities, and toleranceImproves venous reflux in patients
Marastoni et al., 1982 [39]Night cramps, painful limbs, numbness, heaviness, orthostatic oedema, and altered skin trophismImproves clinical observations of venous insufficiency and venous tone
Pointel et al., 1987 [40]Venous distensibility, % of patients with improved heaviness in legs, oedema, and standing leg painTTFCA is well tolerated and superior to placebo in the treatment of venous insufficiency
Cesarone et al., 1994 [41]RF, tcPCO2, and tcPO2Effective in venous hypertensive microangiopathy
Cesarone et al., 2001a [42]RF, CFR (measured as RAS)Improves microcirculation with venous hypertension and venous microangiopathy
Cesarone et al., 2001b [43]RF, VAR, tcPCO2, tcPO2, and RTImproves microcirculation and leg volume in venous hypertension
De Sanctis et al., 2001 [44]CFR, RTReduces the increased capillary filtration in patients with venous hypertension
Incandela et al., 2001 [45]BRF, VAR, tcPCO2, and tcPO2Useful for treatment of venous hypertensive microangiopathy

BRF: baseline resting flow.
CFR: capillary filtration rate.
tcPCO2: transcutaneous pressure of carbon dioxide.
tcPO2: transcutaneous pressure of oxygen.
RAS: rate of ankle swelling.
RF: resting flux.
RT: refilling time.
VAR: venoarteriolar response.