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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 647452, 10 pages
Research Article

A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry

1Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Science, Beijing 100700, China
2Department of Medicinal Chemistry of Nature Product, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3Jiangxi Qingfeng Pharmaceutical Inc., Ganzhou 341000, China
4School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong

Received 12 November 2012; Revised 23 December 2012; Accepted 28 December 2012

Academic Editor: Wei Jia

Copyright © 2013 Cheng Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Hand-foot-and-mouth disease (HFMD), with poorly understood pathogenesis, has become a major public health threat across Asia Pacific. In order to characterize the metabolic changes of HFMD and to unravel the regulatory role of clinical intervention, we have performed a metabolomics approach in a clinical trial. In this study, metabolites profiling was performed by liquid chromatography/quadrupole time-of-flight mass spectrometry (LC-Q-TOF-MS) platform from the HFMD clinical patient samples. The outcome of this study suggested that 31 endogenous metabolites were mainly involved and showed marked perturbation in HFMD patients. In addition, combination therapy intervention showed normalized tendency in HFMD patients in differential pathway. Taken together, these results indicate that metabolomics approach can be used as a complementary tool for the detection and the study of the etiology of HFMD.