A Metabolomics Profiling Study in Hand-Foot-and-Mouth Disease and Modulated Pathways of Clinical Intervention Using Liquid Chromatography/Quadrupole Time-of-Flight Mass Spectrometry
Significant molecular network of combination therapy related metabolites. Metabolites are represented as nodes, and the biological relationship between two nodes is represented as a line. Note that the colored symbols represent metabolites that occur in our data, while the transparent entries are molecules from the Ingenuity Knowledge Database. Red symbols represent up-regulated metabolites in HFMD patients after combination therapy; green symbols represent down-regulated metabolites in HFMD patients after combination therapy. Solid lines between molecules indicate direct physical relationship between molecules; dotted lines indicate indirect functional relationships. The yellow dashed area denotes the related pathway.