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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 658531, 15 pages
Research Article

A Computational Drug-Target Network for Yuanhu Zhitong Prescription

1Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, No. 16 Nanxiaojie, Dongzhimennei, Beijing 100700, China
2Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China
3Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China
4Capital Medical University, Beijing 100069, China

Received 20 December 2012; Accepted 10 March 2013

Academic Editor: Shao Li

Copyright © 2013 Haiyu Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [17 citations]

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  • Ming Yang, Jia-Lei Chen, Li-Wen Xu, and Guang Ji, “Navigating Traditional Chinese Medicine Network Pharmacology and Computational Tools,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, pp. 1–23, 2013. View at Publisher · View at Google Scholar
  • Hai-Yu Xu, Lu-Qi Huang, Song-Song Wang, Hong-Jun Yang, Shou-Sheng Tian, Dong-Hang Wang, Bao-Lin Bian, Peng Lu, Xiang-Shan Zhou, and Jin-Hua You, “Study on action mechanism of adjuvant therapeutic effect compound Ejiao slurry in treating cancers based on network pharmacology,” Zhongguo Zhongyao Zazhi, vol. 39, no. 16, pp. 3148–3151, 2014. View at Publisher · View at Google Scholar
  • Haiyu Xu, Yanqiong Zhang, Yun Lei, Xiumei Gao, Huaqiang Zhai, Na Lin, Shihuan Tang, Rixin Liang, Yan Ma, Defeng Li, Yi Zhang, Guangrong Zhu, Hongjun Yang, and Luqi Huang, “A Systems Biology-Based Approach to Uncovering the Molecular Mechanisms Underlying the Effects of Dragon's Blood Tablet in Colitis, Involving the Integration of Chemical Analysis, ADME Prediction, and Network Pharmacology,” Plos One, vol. 9, no. 7, 2014. View at Publisher · View at Google Scholar
  • Yinli Liu, Bin Chen, Jian Le, Yanhai Xu, Lin Song, Yifeng Chai, Guorong Fan, and Zhanying Hong, “Rapid and sensitive liquid chromatography with tandem mass spectrometry method for the simultaneous determination of 11 major components of Yuanhu-Baizhi herb-pair in rat perfusion fluids,” Journal of Separation Science, vol. 37, no. 12, pp. 1429–1437, 2014. View at Publisher · View at Google Scholar
  • Hai-Yu Xu, and Hong-Jun Yang, “Integrative pharmacology: new paradigm of modernization of Chinese medicine,” Zhongguo Zhongyao Zazhi, vol. 39, no. 3, pp. 357–362, 2014. View at Publisher · View at Google Scholar
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