Research Article
A Computational Drug-Target Network for Yuanhu Zhitong Prescription
Table 1
Six metabolites of YZP detected in vivo from the previous experiment.
| No. | RT (min) | [M + H]+ | Formula | Metabolite name | Formula change | Parent compound | Source |
| M1 | 4.1880 | 342.1333 | C19H19NO5 | Demethylation, hydrogenation | −CH2+H2 | Protopine | Plasma | M2 | 9.08278 | 342.1691 | C20H23NO4 | Demethylation | −CH2 | Tetrahydropalmatine | Plasma | M3 | 10.6147 | 342.1695 | C20H23NO4 | Demethylation | −CH2 | Tetrahydropalmatine | Plasma, CSF | M4 | 21.8366 | 301.0715 | C16H12O6 | Methylene to ketone | +O–H2 | Oxypeucedanin | Plasma | M5 | 5.21887 | 326.1384 | C19H19NO4 | Demethylation | −CH2 | Tetrahydroberberine | Plasma, CSF | M6 | 8.0093 | 326.1386 | C19H19NO4 | Demethylation | −CH2 | Tetrahydroberberine | Plasma |
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CSF: cerebrospinal fluid.
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