Research Article
Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation
Table 6
Frequency of nuclear division (NDI), micronucleated binucleated cells (MNCBNs), and micronucleated polychromatic erythrocytes (MNPCEs) after treatment with different concentrations of propolis water extract and their respective controls.
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MMS: methyl methanesulfonate (44 g/mL); CPA: cyclophosphamide (50 mg/kg b.w.). a500 binucleated cells were analysed per culture, corresponding to a total of 1500 cells per treatment. b1000 binucleated cells were counted per culture, corresponding to a total of 3000 cells per treatment. c400 erythrocytes were analysed per animal, corresponding to a total of 2400 cells per treatment. d2000 erythrocytes were analysed per animal, corresponding to a total of 12,000 cells per treatment. The values are presented as the mean ± standard deviation. *Significantly different from the negative control group (). |