Evaluation of a Propolis Water Extract Using a Reliable RP-HPLC Methodology and In Vitro and In Vivo Efficacy and Safety Characterisation

Table 7

Mean values for the initial and final weight, weight gained, and water consumption obtained from Swiss mice treated with propolis water extract for 7 days and respective controls. The values are presented as the mean ± standard deviation.

Treatments; (mg/kg b.w.)	Initial weight; (g)	Final weight; (g)	Weight gain; (g)	Water consumption; (mL/animal/day)
Negative control	21.25 ± 3.18	23.00 ± 3.53	1.75 ± 0.35	4.64 ± 3.66
7	30.08 ± 0.49	30.75 ± 0.82	0.67 ± 0.52	4.17 ± 2.26
14	23.58 ± 1.88	28.67 ± 1.12	5.08 ± 2.15	9.59 ± 3.53
21	28.25 ± 1.72	29.50 ± 2.37	1.25 ± 1.08	9.97 ± 4.26
CPA	25.25 ± 2.81	27.33 ± 2.25	2.08 ± 0.74	3.81 ± 2.72

CPA: cyclophosphamide (50 mg/kg b.w.).