Interaction of Acupuncture and Electroacupuncture on the Pharmacokinetics of Aspirin and the Effect of Brain Blood Flow in Rats

Table 2

The pharmacokinetic parameters of salicylic acid for the rat brain. The control group (aspirin administration 30 mg/kg only); the acupuncture group (acupuncture stimulation 15 min before aspirin administration 30 mg/kg); the electro-acupuncture group (electro-acupuncture stimulation 15 min before aspirin administration 30 mg/kg).

Parameter	Aspirin (30 mg/kg)	Aspirin (30 mg/kg) + acupuncture	Aspirin (30 mg/kg) + electro-acupuncture
𝑡1/2 (min)	370±173	345±123	330±184
AUC (min 𝜇g/mL)	1076±314	919±154	810±70
Cl (mL/min/kg)	21.0±8.3	34.3±14.0	30.7±11.1
Vd (mL/kg)	8.2±4.2	14.0±4.9	9.1±2.2

Data expressed as mean ± S.E.M. (𝑛=6). 𝑡_1/2: elimination half-life, AUC: area under the concentration-time curve, Cl: clearance, Vd: apparent volume of distribution.