Ixeris dentata NAKAI Reduces Clinical Score and HIF-1 Expression in Experimental Colitis in Mice

Figure 2

The effect of Ixeris dentata NAKAI (ID) on serum levels of interleukin- (IL-) 6 and tumor-necrosis-factor- (TNF-) α in DSS-induced colitis. Ulcerative colitis was induced by administering 5% DSS in the drinking water for seven days. Over the same period, ID (100 mg/kg) and the reference compound sulfasalazine (SFZ; 100 mg/kg) were given orally once daily. Cytokine production was determined by ELISA. (a) IL-6 production in mouse serum at day 7. (b) TNF-α production in mouse serum at day 7. (c) IL-6 production in colon tissue. (d) TNF-α production in colon tissue. Values represent mean ± S.E.M. (𝑛=5). Data were analyzed by Student’s 𝑡 test (^#𝑃<0.05 versus control and ^∗𝑃<0.05 versus DSS alone).

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