Evaluation of the Add-On Effect of Chinese Patent Medicine for Patients with Stable or Unstable Angina: A Systematic Review and Meta-Analysis

Table 3

Chinese herbal medicine plus western medicine versus western medicine alone for treating stable angina: meta-analysis results.

Events	No. of studies	No. of events/total no.		Combined effect		Heterogeneity
		CHM	Control	RR (95% CI)	𝑃 value	𝑄 value	𝑃 value	𝐼^2
Stable angina
Total heart events	3	23/150	45/147	0.50 (0.33–0.78)	0.002	0.39	0.825	0.0
Death	2	2/115	6/115	0.38 (0.09–1.61)	0.190	0.01	0.920	0.0
Myocardial infarction	7	6/324	21/315	0.32 (0.14–0.72)	0.006	1.34	0.970	0.0
Cardiac arrhythmia	2	7/93	25/92	0.27 (0.13–0.57)	0.001	0.28	0.594	0.0
Heart failure	3	6/168	16/165	0.37 (0.15–0.91)	0.031	0.27	0.875	0.0
Angina	6	26/306	55/298	0.46 (0.30–0.71)	<0.001	2.75	0.739	0.0
Fatal events	1	1/45	2/42	0.47 (0.04–4.96)	0.527	—	—	—
Sudden cardiac death	1	2/50	3/50	0.67 (0.12–3.82)	0.649	—	—	—
Bleeding	1	1/40	1/36	0.90 (0.06–13.87)	0.940	—	—	—
Stomach discomfort	1	2/55	4/55	0.50 (0.10–2.62)	0.653	—	—	—
Unstable angina
Total heart events	7	36/337	78/333	0.46 (0.32–0.66)	<0.001	1.15	0.979	0.0
Death	1	0/40	2/38	0.19 (0.01–3.84)	0.279	—	—	—
Myocardial infarction	19	33/775	92/741	0.37 (0.26–0.54)	<0.001	14.32	0.708	0.0
Cardiac arrhythmia	1	5/50	10/50	0.50 (0.18–1.36)	0.174	—	—	—
Heart failure	2	5/80	12/77	0.41 (0.15–1.09)	0.075	0.10	0.754	0.0
Angina	12	40/585	99/533	0.36 (0.26–0.51)	<0.001	7.79	0.732	0.0
Fatal events	4	0/147	4/147	0.33 (0.07–1.62)	0.173	0.00	1.000	0.0
Sudden cardiac death	5	0/243	9/243	0.22 (0.06–0.84)	0.027	0.08	0.999	0.0
Cardiac surgery	2	2/56	7/56	0.29 (0.06–1.32)	0.108	0.33	0.564	0.0
PCI	3	3/118	9/117	0.35 (0.11–1.16)	0.088	0.96	0.618	0.0
Bleeding	1	1/31	11/31	0.09 (0.01–0.66)	0.018	—	—	—
Stomach discomfort	2	1/63	3/63	0.67 (0.11–3.90)	0.653	1.49	0.222	32.8
Stable angina or unstable angina
Total heart events	1	3/39	7/39	0.43 (0.12–1.54)	0.194	—	—	—
Death	2	6/173	11/202	0.58 (0.23–1.48)	0.256	0.32	0.570	0.0
Myocardial infarction	4	10/320	31/348	0.34 (0.17–0.68)	0.002	0.46	0.984	0.0
Cardiac arrhythmia	1	2/30	4/30	0.50 (0.10–2.53)	0.402	—	—	—
Heart failure	2	12/110	26/109	0.46 (0.24–0.86)	0.015	0.21	0.646	0.0
Angina	4	25/210	54/208	0.46 (0.30–0.70)	<0.001	0.70	0.874	0.0
Fatal events	2	4/110	9/109	0.44 (0.14–1.39)	0.161	0.01	0.903	0.0
Sudden cardiac death	1	1/61	3/60	0.33 (0.04–3.06)	0.328	—	—	—
Cardiac operation	1	8/80	16/79	0.49 (0.22–1.09)	0.080	—	—	—
Bleeding	1	1/40	1/36	0.90 (0.06–13.87)	0.940	—	—	—
Stomach discomfort	3	8/130	2/129	2.99 (0.83–10.73)	0.094	1.04	0.594	0.0

CHM: chinese herbal medicine; RR: risk ratio; CI: confidence interval; PCI: percutaneous transluminal coronary intervention.