The Inhibitory Effect of 3β-Hydroxy-12-oleanen-27-oic Acid on Growth and Motility of Human Hepatoma HepG2 Cells through JNK and Akt Signaling Pathway

Table 3

Inhibitive effect of 3β-hydroxy-12-oleanen-27-oic acid (ATA) on pulmonary metastasis of B16-F10 melanoma in mice.

Group	Dose (mg/kg)	Body weight (g)	Lung weight (mg)	No. of tumor colonies	Inhibitory rate (%)
Normal control	—	20.99±2.88	139.86±17.01	—	—
Model control	—	20.09±1.85	212.20±14.85	54.33±11.75	—
CY	50	20.74±2.44	157.84±11.58^∗∗∗	12.00±6.20^∗∗∗	77.91
ATA	20	20.80±2.35	177.97±16.01^∗∗	23.38±11.49^∗∗∗	56.96
	40	20.28±2.34	159.43±12.74^∗∗∗	16.29±6.74^∗∗∗	70.03
	60	20.58±2.06	150.64±13.06^∗∗∗	11.80±9.91^∗∗∗	78.28

The values are presented as means ± SD (𝑛=10). Significant differences with model control were designated as ^∗∗𝑃<0.01 or ^∗∗∗𝑃<0.001. CY: cyclophosphamide (positive drug).