Antidiabetic Effect and Mode of Action of Cytopiloyne

Table 1

Blood glucose levels following a single oral dose of cytopiloyne in fed db/db mice. Diabetic db/db mice aged 6 to 8 weeks, with free access to food, were grouped and tube-fed with vehicle, glimepiride (GLM) at 2.5 mg/kg/day, and cytopiloyne (CP) at 0.1, 0.5, and 2.5 mg/kg/day. A half-hour after tube feeding was set as time 0. Blood samples were collected from the mice at the indicated time intervals (0, 1, 2, and 4 h). The blood glucose levels were determined using a glucometer. The number of mice (𝑛) tested is indicated in parentheses in the first column.

Treatment	Blood glucose level (mg/dL)
	0	1	2	4 (h)
Vehicle (𝑛=8)	365 ± 9	309 ± 4	281 ± 9	240 ± 11
GLM 2.5 mg/kg (𝑛=5)	378 ± 9	237 ± 16*	178 ± 20*	187 ± 6*
CP 0.1 mg/kg (𝑛=7)	373 ± 6	267 ± 12	204 ± 17*	158 ± 18*
CP 0.5 mg/kg (𝑛=7)	369 ± 27	214 ± 15*	163 ± 8*	132 ± 11*
CP 2.5 mg/kg (𝑛=7)	365 ± 9	207 ± 11*	147 ± 12*	129 ± 11*

^∗𝑃<0.05 as determined by ANOVA.