Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway
Figure 4
Effects of H/R on AKT and MAPK signaling pathways in H9c2 cardiomyocytes. H9c2 cardiomyocytes were exposed to 6 h of hypoxia followed by 48 h reoxygenation. Then the expression levels of phosphorylated and total AKT (a), ERK1/2 (b), JNK (c), and p38 (d) were detected by immunoblotting assay at 0, 6, 12, 24, and 48 h after reoxygenation. The percentage values of the p-AKT/AKT, p-ERK1/2/ERK1/2, p-JNK/JNK, and p-p38/p38 ratios relative to the control condition are shown. Normalization of Western blots was ensured by β-actin. The results are represented as means ± SD from three independent experiments. * versus control group.
