Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells
Figure 4
sBr treatment throughout sensitization prevents generation of OVA-specific CD8+ T-cell response. Animals were sacrificed after each weekly OVA-alum i.p. Spleen and nodes were pooled and enriched for OVA-specific CD8+ T cells via SIINFEKL () loaded tetramer. As compared to PBS-treated controls, sBr treatment significantly limited the expansion of total OVA-TET+ CD8+ T cells after each weekly OVA-alum i.p. ( compared to PBS; –5 per group).
