Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013 (2013), Article ID 707285, 10 pages
http://dx.doi.org/10.1155/2013/707285
Research Article

Acute and Subchronic Toxic Effects of the Fruits of Physalis peruviana L.

1Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey
2Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskisehir, Turkey
3Department of Pharmacology, Faculty of Medicine, Osmangazi University, 26480 Eskisehir, Turkey

Received 5 September 2013; Accepted 27 October 2013

Academic Editor: I-Min Liu

Copyright © 2013 Basak Ozlem Perk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. I. Ahmad, F. Aqil, F. Ahmad, and M. Owais, “Herbal medicines: prospects and constraints,” in Modern Phytomedicine: Turning Medicinal Plants Into Drugs, Wiley-Vch, 2006. View at Publisher · View at Google Scholar
  2. A. Shirwaikar, R. Verma, R. Lobo, and A. Shirwaikar, “Phytotherapy-safety aspects,” Natural Product Radiance, vol. 8, no. 1, pp. 55–63, 2009. View at Google Scholar · View at Scopus
  3. M. F. R. Hassanien, “Physalis peruviana: a rich source of bioactive phytochemicals for functional foods and pharmaceuticals,” Food Reviews International, vol. 27, no. 3, pp. 259–273, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. F. Mericli, “Bilimsel acidan altin cilek meyveleri (Physalis peruviana),” Fitomed, vol. 20, pp. 18–22, 2011. View at Google Scholar
  5. “Turkish Plants Data Service (TUBIVES),” http://turkherb.ibu.edu.tr/.
  6. M. F. Ramadan, “Bioactive phytochemicals, nutritional value, and functional properties of cape gooseberry (Physalis peruviana): an overview,” Food Research International, vol. 44, no. 7, pp. 1830–1836, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. E. Rodrigues, I. I. Rockenbach, C. Cataneo, L. V. Gonzaga, E. S. Chaves, and R. Fett, “Minerals and essential fatty acids of the exotic fruit Physalis peruviana L,” Food Science and Technology, vol. 29, no. 3, pp. 642–645, 2009. View at Google Scholar · View at Scopus
  8. M. Valdenegro, C. Henriquez, M. Lutz, S. Almonacid, and R. Simpson, “Drum dried, liophylized dried and traditional drying of goldenberry (Physalis peruviana L.): effects in nutritional and healthy quality,” in Proceedings of the International Conference on Food Innovation, Food Innova, Valencia, Calif, USA, October2010.
  9. C.-Y. Yen, C.-C. Chiu, F.-R. Chang et al., “4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest,” BMC Cancer, vol. 10, article 46, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. L. A. Puente, C. A. P. Muñoz, E. S. Castro, and M. Cortés, “Physalis peruviana Linnaeus, the multiple properties of a highly functional fruit: a review,” Food Research International, vol. 44, pp. 1733–1740, 2011. View at Google Scholar
  11. M. Gunaydin, O. Tatli, G. Altuntas, B. Abanoz, E. S. Seyhanli, and A. A. Top, “Golden Strawberry could have been caused subarachnoid hemorrhage?” in Proceedings of the 9th National Emergency Medicine Congress, Antalya, Turkey, 2013.
  12. H. Simsek, A. Dogan, M. Islek, H. A. Gumrukcuoglu, and M. Sahin, “A case of ventricular tachycardia resulting from used of golden berry fruit extract pills,” in Proceedings of the 27th National Cardiology Congress, Istanbul, Turkey, 2011.
  13. O. Yanartes, Y. Yilmaz, M. B. Baykaran, I. Saygili, and S. B. Zincir, “A manic episode induced by herbal preparate golden berry (cape gooseberry) (Physalis peruviana L),” Journal of Mood Disorders, vol. 2, no. 1, pp. 12–14, 2012. View at Google Scholar
  14. J. M. Pardo, M. R. Fontanilla, L. F. Ospina, and L. Espinosa, “Determining the pharmacological activity of Physalis peruviana fruit juice on rabbit eyes and fibroblast primary cultures,” Investigative Ophthalmology and Visual Science, vol. 49, no. 7, pp. 3074–3079, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S.-T. Fang, B. Li, and J.-K. Liu, “Two new withanolides from Physalis peruviana,” Helvetica Chimica Acta, vol. 92, no. 7, pp. 1304–1308, 2009. View at Publisher · View at Google Scholar · View at Scopus
  16. S. T. Fang, J. K. Liu, and B. Li, “A novel 1,10-seco withanolide from Physalis peruviana,” Journal of Asian Natural Products Research, vol. 12, no. 7, pp. 618–622, 2010. View at Publisher · View at Google Scholar · View at Scopus
  17. Y.-H. Lan, F.-R. Chang, M.-J. Pan et al., “New cytotoxic withanolides from Physalis peruviana,” Food Chemistry, vol. 116, no. 2, pp. 462–469, 2009. View at Publisher · View at Google Scholar · View at Scopus
  18. W. Martínez, L. F. Ospina, D. Granados, and G. Delgado, “In vitro studies on the relationship between the anti-inflammatory activity of Physalis peruviana extracts and the phagocytic process,” Immunopharmacology and Immunotoxicology, vol. 32, no. 1, pp. 63–73, 2010. View at Publisher · View at Google Scholar · View at Scopus
  19. Á. C. Mora, D. M. Aragón, and L. F. Ospina, “Effects of Physalis peruviana fruit extract on stress oxidative parameters in streptozotocin-diabetic rats,” Latin American Journal of Pharmacy, vol. 29, no. 7, pp. 1132–1136, 2010. View at Google Scholar · View at Scopus
  20. C. Loan, “Methodology for the analysis of vegetable drugs,” in Practical Manual on the Industrial Utilisation of Medicinal and Aromatic Plants, Center Building, 1982. View at Google Scholar
  21. I. W. Sizer, “The biuret and ninhydrin tests for proteins as measured with Hardy's spectrophotometer,” Experimental Biology and Medicine, vol. 37, no. 1, pp. 107–110, 1937. View at Google Scholar
  22. W. C. Evans, Trease and Evans Pharmacognosy, WB Saunders, London, UK, 15th edition, 2002.
  23. U. A. Stephen, F. Abiodun, O. Osahon, and E. Ewaen, “Phytochemical analysis and antibacterial activity of Khaya grandifoliola stem bark,” Journal of Biological Sciences, vol. 9, no. 1, pp. 63–67, 2009. View at Publisher · View at Google Scholar · View at Scopus
  24. I.-S. Shin, Y.-B. Yu, C.-S. Seo et al., “Subchronic toxicity of Sipjeondaebo-tang (SDT) in Sprague-Dawley rats,” Regulatory Toxicology and Pharmacology, vol. 59, no. 3, pp. 375–384, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Y. Lee, I. S. Shin, C. S. Seo, J. H. Kim, S. R. Han, and H. K. Shin, “Subchronic oral toxicity studies of the traditional herbal formula Bangpungtongseong-san in Crl: CD, (SD) rats,” Journal of Ethnopharmacology, vol. 144, no. 3, pp. 720–725, 2012. View at Google Scholar
  26. G. Reifferscheid and J. Heil, “Validation of the SOS/umu test using test results of 486 chemicals and comparison with the Ames test and carcinogenicity data,” Mutation Research, vol. 369, no. 3-4, pp. 129–145, 1996. View at Google Scholar · View at Scopus
  27. M. Kamber, S. Flückiger-Isler, G. Engelhardt, R. Jaeckh, and E. Zeiger, “Comparison of the Ames II and traditional Ames test responses with respect to mutagenicity, strain specificities, need for metabolism and correlation with rodent carcinogenicity,” Mutagenesis, vol. 24, no. 4, pp. 359–366, 2009. View at Publisher · View at Google Scholar · View at Scopus
  28. R. Hunt, R. Fedorak, J. Frohlich, C. McLennan, and A. Pavilanis, “Therapeutic role of dietary fibre,” Canadian Family Physician, vol. 39, pp. 897–903, 1993. View at Google Scholar · View at Scopus
  29. M. Elleuch, D. Bedigian, O. Roiseux, S. Besbes, C. Blecker, and H. Attia, “Dietary fibre and fibre-rich by-products of food processing: characterisation, technological functionality and commercial applications: a review,” Food Chemistry, vol. 124, no. 2, pp. 411–421, 2011. View at Publisher · View at Google Scholar · View at Scopus
  30. F. F. Vasanwala, “Managament of chronic constipation in the elderly,” The Singapore Family Physician, vol. 35, no. 3, pp. 84–92, 2009. View at Google Scholar
  31. H. Olson, G. Betton, D. Robinson et al., “Concordance of the toxicity of pharmaceuticals in humans and in animals,” Regulatory Toxicology and Pharmacology, vol. 32, no. 1, pp. 56–67, 2000. View at Publisher · View at Google Scholar · View at Scopus
  32. National Heart, Blood and Lung Institute, http://www.nhlbi.nih.gov/health//dci/Diseases/thrm/thrm_causes.html.
  33. A. Ihsan, X. Wang, X.-J. Huang et al., “Acute and subchronic toxicological evaluation of Mequindox in Wistar rats,” Regulatory Toxicology and Pharmacology, vol. 57, no. 2-3, pp. 307–314, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. S. Y. Hor, M. Ahmad, E. Farsi, C. P. Lim, M. Z. Asmawi, and M. F. Yam, “Acute and subchronic oral toxicity of Coriolus versicolor standardized water extract in Sprague-Dawley rats,” Journal of Ethnopharmacology, vol. 137, no. 3, pp. 1067–1076, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. S. K. Ramaiah, “A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters,” Food and Chemical Toxicology, vol. 45, no. 9, pp. 1551–1557, 2007. View at Publisher · View at Google Scholar · View at Scopus
  36. H. R. Rasekh, P. Nazari, M. Kamli-Nejad, and L. Hosseinzadeh, “Acute and subchronic oral toxicity of Galega officinalis in rats,” Journal of Ethnopharmacology, vol. 116, no. 1, pp. 21–26, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. M. A. Suckow, K. A. Stevens, and R. P. Wilson, The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents, Academic Press, Seattle, Wash, USA, 2012.
  38. K. Kuroiwa, M. Shibutani, K. Inoue, K.-Y. Lee, G.-H. Woo, and M. Hirose, “Subchronic toxicity study of water pepper extract in F344 rats,” Food and Chemical Toxicology, vol. 44, no. 8, pp. 1236–1244, 2006. View at Publisher · View at Google Scholar · View at Scopus
  39. S. Kulthinee, J. M. Wyss, D. Jirakulsomchok, and S. Roysommuti, “High sugar intake exacerbates cardiac reperfusion injury in perinatal taurine depleted adult rats,” Journal of Biomedical Science, vol. 17, no. 1, article S22, 2010. View at Publisher · View at Google Scholar · View at Scopus
  40. P. J. O'Brien, “Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity,” Toxicology, vol. 245, no. 3, pp. 206–218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Walker, “Serum chemical biomarkers of cardiac injury for nonclinical safety testing,” Toxicologic Pathology, vol. 34, no. 1, pp. 94–104, 2006. View at Publisher · View at Google Scholar · View at Scopus
  42. M. J. Smit, H. Beekhuis, A. M. Duursma, J. M. W. Bouma, and M. Gruber, “Catabolism of circulating enzymes: plasma clearance, endocytosis, and breakdown of lactate dehydrogenase-1 in rabbits,” Clinical Chemistry, vol. 34, no. 12, pp. 2475–2480, 1988. View at Google Scholar · View at Scopus
  43. M. Kemp, J. Donovan, H. Higham, and J. Hooper, “Biochemical markers of myocardial injury,” British Journal of Anaesthesia, vol. 93, no. 1, pp. 63–73, 2004. View at Publisher · View at Google Scholar · View at Scopus
  44. A. Dolci and M. Panteghini, “The exciting story of cardiac biomarkers: from retrospective detection to gold diagnostic standard for acute myocardial infarction and more,” Clinica Chimica Acta, vol. 369, no. 2, pp. 179–187, 2006. View at Publisher · View at Google Scholar · View at Scopus
  45. L. A. Leinwand, “Sex is a potent modifier of the cardiovascular system,” Journal of Clinical Investigation, vol. 112, no. 3, pp. 302–307, 2003. View at Publisher · View at Google Scholar · View at Scopus
  46. J. M. Orshal and R. A. Khalil, “Gender, sex hormones, and vascular tone,” The American Journal of Physiology, vol. 286, no. 2, pp. R233–R249, 2004. View at Google Scholar · View at Scopus
  47. R. K. Dubey, B. Imthurn, M. Barton, and E. K. Jackson, “Vascular consequences of menopause and hormone therapy: importance of timing of treatment and type of estrogen,” Cardiovascular Research, vol. 66, no. 2, pp. 295–306, 2005. View at Publisher · View at Google Scholar · View at Scopus
  48. V. Bittner, “Menopause, age, and cardiovascular risk: a complex relationship,” Journal of the American College of Cardiology, vol. 54, no. 25, pp. 2374–2375, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. M. A. Carey, C. W. Card, J. M. Voltz et al., “It’s all about sex: male-female differences in lung development and disease,” Trends in Endocrinology and Metabolism, vol. 18, no. 8, pp. 308–313, 2007. View at Google Scholar
  50. C. A. Warnes, “Sex differences in congenital heart disease: should a woman be more like a man?” Circulation, vol. 118, no. 1, pp. 3–5, 2008. View at Publisher · View at Google Scholar · View at Scopus
  51. C. S. Zoltani, Cardiovascular Toxicity, Veterinary Toxicology, Academic Press, New York, NY, USA, 2nd edition, 2012.