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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 721729, 12 pages
http://dx.doi.org/10.1155/2013/721729
Research Article

Sang-qi Granula Reduces Blood Pressure and Myocardial Fibrosis by Suppressing Inflammatory Responses Associated with the Peroxisome Proliferator-Activated Receptors and Nuclear Factor κB Protein in Spontaneously Hypertensive Rats

1China-Japan Freindship Hospital, China
2Tasly Microcirculation Research Center, Peking University Health Science Center, Beijing, China

Received 22 March 2013; Revised 8 August 2013; Accepted 18 August 2013

Academic Editor: Hao Xu

Copyright © 2013 Lan-Yu Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. Li and L. Huang, “SQ granule inhibits myocardial fibrosis in spontaneously hypertension rats,” Chinese Journal of Microcirculation, vol. 20, 2010. View at Google Scholar
  2. P. Delerive, J. C. Fruchart, and B. Staels, “Peroxisome proliferator-activated receptors in inflammation control,” Journal of Endocrinology, vol. 169, no. 3, pp. 453–459, 2001. View at Publisher · View at Google Scholar · View at Scopus
  3. N. Marx, G. K. Sukhova, T. Collins, P. Libby, and J. Plutzky, “PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells,” Circulation, vol. 99, no. 24, pp. 3125–3131, 1999. View at Google Scholar · View at Scopus
  4. P. M. Barger, J. M. Brandt, T. C. Leone, C. J. Weinheimer, and D. P. Kelly, “Deactivation of peroxisome proliferator-activated receptor-α during cardiac hypertrophic growth,” The Journal of Clinical Investigation, vol. 105, no. 12, pp. 1723–1730, 2000. View at Google Scholar · View at Scopus
  5. A. Jones, R. Deb, E. Torsney et al., “Rosiglitazone reduces the development and rupture of experimental aortic aneurysms,” Circulation, vol. 119, no. 24, pp. 3125–3132, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Takeda, T. Ichiki, T. Tokunou et al., “Peroxisome proliferator-activated receptor γ activators downregulate angiotensin II type 1 receptor in vascular smooth muscle cells,” Circulation, vol. 102, no. 15, pp. 1834–1839, 2000. View at Google Scholar · View at Scopus
  7. A. Sugawara, A. Uruno, M. Kudo, K. Matsuda, C. W. Yang, and S. Ito, “Effects of PPARγ on hypertension, atherosclerosis, and chronic kidney disease,” Endocrine Journal, vol. 57, no. 10, pp. 847–852, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Benkirane, É. C. Viel, F. Amiri, and E. L. Schiffrin, “Peroxisome proliferator-activated receptor γ regulates angiotensin II-stimulated phosphatidylinositol 3-kinase and mitogen-activated protein kinase in blood vessels in vivo,” Hypertension, vol. 47, no. 1, pp. 102–108, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. J. Ma, M. Wei, Q. Wang, and T. Peng, “Deficiency of capn4 gene inhibits nuclear factor- κB (NF- κB) protein signaling/inflammation and reduces remodeling after myocardial infarction,” Journal of Biological Chemistry, vol. 287, pp. 27480–27489, 2012. View at Google Scholar
  10. H. J. Maier, T. G. Schips, A. Wietelmann, and T. Wirth, “Cardiomyocyte-speci ficIκB kinase (IKK)/NF- κ Bactivation induces reversible inflammatory cardiomyopathy and heart failure,” PNAS, vol. 109, pp. 11794–11799, 2012. View at Google Scholar
  11. E. M. Seymour, M. R. Bennink, S. W. Watts, and S. F. Bolling, “Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor κB activity and cytokine expression in rats with diastolic dysfunction,” Hypertension, vol. 55, no. 5, pp. 1179–1185, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. T. Ogata, T. Miyauchi, S. Sakai, M. Takanashi, Y. Irukayama-Tomobe, and I. Yamaguchi, “Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-κ-B pathway,” Journal of the American College of Cardiology, vol. 43, no. 8, pp. 1481–1488, 2004. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. H. Smeets, B. E. J. Teunissen, A. Planavila et al., “Inflammatory pathways are activated during cardiomyocyte hypertrophy and attenuated by peroxisome proliferator-activated receptors PPARα and PPARγ,” The Journal of Biological Chemistry, vol. 283, no. 43, pp. 29109–29118, 2008. View at Publisher · View at Google Scholar · View at Scopus
  14. K. Sun, Q. Hu, C. M. Zhou et al., “Cerebralcare granule®, a chinese herb compound preparation, improves cerebral microcirculatory disorder and hippocampal CA1 neuron injury in gerbils after ischemia-reperfusion,” Journal of Ethnopharmacology, vol. 130, no. 2, pp. 398–406, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. J. S. Swaney, D. M. Roth, E. R. Olson, J. E. Naugle, J. G. Meszaros, and P. A. Insel, “Inhibition of cardiac myofibroblast formation and collagen synthesis by activation and overexpression of adenylyl cyclase,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 2, pp. 437–442, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. P. L. Bu, X. Q. Zhao, L. L. Wang, Y. X. Zhao, C. B. Li, and Y. Zhang, “Tong-xin-luo capsule inhibits left venticular remodeling in spontaneously hypertensive rats by enhancing PPAR-γ expression and suppressing NF-κB activity,” Chinese Medical Journal, vol. 121, no. 2, pp. 147–154, 2008. View at Google Scholar · View at Scopus
  17. G. A. Walker, K. S. Masters, D. N. Shah, K. S. Anseth, and L. A. Leinwand, “Valvular myofibroblast activation by transforming growth factor-β: implications for pathological extracellular matrix remodeling in heart valve disease,” Circulation Research, vol. 95, no. 3, pp. 253–260, 2004. View at Publisher · View at Google Scholar · View at Scopus
  18. K. T. Weber, “Fibrosis and hypertensive heart disease,” Current Opinion in Cardiology, vol. 15, pp. 264–272, 2000. View at Google Scholar
  19. A. Nicoletti and J. B. Michel, “Cardiac fibrosis and inflammation: interaction with hemodynamic and hormonal factors,” Cardiovascular Research, vol. 41, no. 3, pp. 532–543, 1999. View at Publisher · View at Google Scholar · View at Scopus
  20. W. A. Border and N. A. Noble, “Transforming growth factor β in tissue fibrosis,” The New England Journal of Medicine, vol. 331, no. 19, pp. 1286–1292, 1994. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Ogata, T. Miyauchi, S. Sakai, M. Takanashi, Y. Irukayama-Tomobe, and I. Yamaguchi, “Myocardial fibrosis and diastolic dysfunction in deoxycorticosterone acetate-salt hypertensive rats is ameliorated by the peroxisome proliferator-activated receptor-alpha activator fenofibrate, partly by suppressing inflammatory responses associated with the nuclear factor-κ-B pathway,” Journal of the American College of Cardiology, vol. 43, no. 8, pp. 1481–1488, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. I. Shahar, E. Fireman, M. Topilsky et al., “Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases,” Clinical Immunology and Immunopathology, vol. 79, no. 3, pp. 244–251, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. S. Gupta, N. H. Purcell, A. Lin, and S. Sen, “Activation of nuclear factor-κB is necessary for myotrophin-induced cardiac hypertrophy,” The Journal of Cell Biology, vol. 159, no. 6, pp. 1019–1028, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. P. F. Gomez, M. H. Pillinger, M. Attur et al., “Resolution of inflammation: prostaglandin E2 dissociates nuclear trafficking of individual NF-κB subunits (p65, p50) in stimulated rheumatoid synovial fibroblasts,” Journal of Immunology, vol. 175, no. 10, pp. 6924–6930, 2005. View at Google Scholar · View at Scopus
  25. W. D. Strayhorn and B. E. Wadzinski, “A novel in vitro assay for deubiquitination of IκBα,” Archives of Biochemistry and Biophysics, vol. 400, no. 1, pp. 76–84, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Frantz, J. Bauersachs, and G. Ertl, “Post-infarct remodelling: contribution of wound healing and inflammation,” Cardiovascular Research, vol. 81, no. 3, pp. 474–481, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Zelarayan, A. Renger, and C. Noack, “NF-κB activation is required for adaptive cardiac hypertrophy,” Cardiovascular Research, vol. 84, no. 3, pp. 416–424, 2009. View at Publisher · View at Google Scholar
  28. S. M. O. 'Donnell, M. W. Hansberger, and J. L. Connolly, “Organ-specific roles for transcription factor NF-κB in reovirus-induced apoptosis and disease,” The Journal of Clinical Investigation, vol. 115, no. 9, pp. 2341–2350, 2005. View at Google Scholar
  29. O. Yokoseki, J. I. Suzuki, H. Kitabayashi et al., “Cis element decoy against nuclear factor-κB attenuates development of experimental autoimmune myocarditis in rats,” Circulation Research, vol. 89, no. 10, pp. 899–906, 2001. View at Google Scholar · View at Scopus
  30. R. Kleemann, P. P. Gervois, L. Verschuren, B. Staels, H. M. G. Princen, and T. Kooistra, “Fibrates down-regulate IL-1-stimulated C-reactive protein gene expression in hepatocytes by reducing nuclear p50-NFκB-C/EBP-β complex formation,” Blood, vol. 101, no. 2, pp. 545–551, 2003. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Bujak, G. Ren, H. J. Kweon et al., “Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling,” Circulation, vol. 116, no. 19, pp. 2127–2138, 2007. View at Publisher · View at Google Scholar · View at Scopus
  32. A. Bobik, “Transforming growth factor-betas and vascular disorders,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, pp. 1712–1720, 2006. View at Google Scholar
  33. R. A. Rahimi and E. B. Leof, “TGF-β signaling: a tale of two responses,” Journal of Cellular Biochemistry, vol. 102, no. 3, pp. 593–608, 2007. View at Publisher · View at Google Scholar · View at Scopus
  34. D. Seo and J. M. Hare, “The transforming growth factor-β/Smad3 pathway: coming of age as a key participant in cardiac remodeling,” Circulation, vol. 116, no. 19, pp. 2096–2098, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. P. Delerive, P. Gervois, J. C. Fruchart, and B. Staels, “Induction of IκBα expression as a mechanism contributing to the anti-inflammatory activities of peroxisome proliferator-activated receptor-α activators,” The Journal of Biological Chemistry, vol. 275, no. 47, pp. 36703–36707, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. P. Delerive, K. de Bosscher, S. Besnard et al., “Peroxisome proliferator-activated receptor α negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-κB and AP-1,” The Journal of Biological Chemistry, vol. 274, no. 45, pp. 32048–32054, 1999. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Marx, G. K. Sukhova, T. Collins, P. Libby, and J. Plutzky, “PPARα activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells,” Circulation, vol. 99, no. 24, pp. 3125–3131, 1999. View at Google Scholar · View at Scopus
  38. Q. N. Diep, K. Benkirane, F. Amiri, J. S. Cohn, D. Endemann, and E. L. Schiffrin, “PPARα activator fenofibrate inhibits myocardial inflammation and fibrosis in angiotensin II-infused rats,” Journal of Molecular and Cellular Cardiology, vol. 36, no. 2, pp. 295–304, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. E. L. Schiffrin, F. Amiri, K. Benkirane, M. Iglarz, and Q. N. Diep, “Peroxisome proliferator-activated receptors: vascular and cardiac effects in hypertension,” Hypertension, vol. 42, no. 4, pp. 664–668, 2003. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Asakawa, H. Takano, T. Nagai et al., “Peroxisome proliferator-activated receptor γ plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo,” Circulation, vol. 105, no. 10, pp. 1240–1246, 2002. View at Publisher · View at Google Scholar · View at Scopus