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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 730734, 8 pages
http://dx.doi.org/10.1155/2013/730734
Research Article

Opposite Effects of Single-Dose and Multidose Administration of the Ethanol Extract of Danshen on CYP3A in Healthy Volunteers

1Lab of Clinical Pharmacokinetics, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
2Lab of Pharmacokinetics, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
3Key Lab of Drug Metabolism & Pharmacokinetics, China Pharmaceutics University, Nanjing 210038, China

Received 10 April 2013; Revised 13 July 2013; Accepted 27 August 2013

Academic Editor: Moses S. S. Chow

Copyright © 2013 Furong Qiu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [11 citations]

The following is the list of published articles that have cited the current article.

  • Furong Qiu, Jin Zeng, Songcan Liu, Min He, Leilei Zhu, Yujie Ye, Ping Miao, Shujiao Shen, and Jian Jiang, “Effects of Danshen Ethanol Extract on the Pharmacokinetics of Fexofenadine in Healthy Volunteers,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, pp. 1–5, 2014. View at Publisher · View at Google Scholar
  • Tao Hu, Xuelin Zhou, Lin Wang, Penelope M.Y. Or, John H.K. Yeung, Yiu Wa Kwan, and Chi Hin Cho, “Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: Enzyme kinetic and molecular docking studies,” Chemico-Biological Interactions, 2015. View at Publisher · View at Google Scholar
  • Bokyung Sung, Hye Chung, Minjung Kim, Yong Kang, Dong Kim, Seong� Hwang, Min Kim, Cheol Kim, Hae Chung, and Nam Kim, “Cytotoxic effects of solvent-extracted active components of Salvia�miltiorrhiza Bunge on human cancer cell lines,” Experimental and Therapeutic Medicine, 2015. View at Publisher · View at Google Scholar
  • Loai Basheer, and Zohar Kerem, “Interactions between CYP3A4 and Dietary Polyphenols,” Oxidative Medicine and Cellular Longevity, vol. 2015, pp. 1–15, 2015. View at Publisher · View at Google Scholar
  • Boyan Liu, Yanhui Du, Lixin Cong, Xiaoying Jia, and Ge Yang, “ Danshen ( Salvia miltiorrhiza ) Compounds Improve the Biochemical Indices of the Patients with Coronary Heart Disease ,” Evidence-Based Complementary and Alternative Medicine, vol. 2016, pp. 1–9, 2016. View at Publisher · View at Google Scholar
  • Yu-Juan Fan, Bo Tan, Yue Li, Jian Jiang, Fu-Rong Qiu, Zhi-Rong Zhang, and Lin-Lin Zhang, “Effects of Danshentong Capsules on Intrahepatic Cholestasis Liver Injury in Mice Induced by ANIT,” Chinese Pharmaceutical Journal, vol. 52, no. 15, pp. 1331–1336, 2017. View at Publisher · View at Google Scholar
  • Yuanyuan Jiang, Li Zhang, and H.P. Vasantha Rupasinghe, “Antiproliferative effects of extracts from Salvia officinalis L. and Saliva miltiorrhiza Bunge on hepatocellular carcinoma cells,” Biomedicine & Pharmacotherapy, vol. 85, pp. 57–67, 2017. View at Publisher · View at Google Scholar
  • Feng Chen, Li Li, and Dan-Dan Tian, “ Salvia miltiorrhiza Roots against Cardiovascular Disease: Consideration of Herb-Drug Interactions ,” BioMed Research International, vol. 2017, pp. 1–12, 2017. View at Publisher · View at Google Scholar
  • Hai-bing Yu, Xiao-Ting Zheng, Zhang-Feng Zhong, Chun-hua Zhou, Meng Xu, and Lan-tong Zhang, “Effects of Danshen capsules on the pharmacokinetics and pharmacodynamics of clopidogrel in healthy volunteers,” Food and Chemical Toxicology, vol. 119, pp. 302–308, 2018. View at Publisher · View at Google Scholar
  • Mei-juan Xu, Li-feng Jiang, Ting Wu, Ji-hong Chu, Yi-dan Wei, Ji-ye Aa, Guang-ji Wang, Hai-ping Hao, Wen-zheng Ju, and Ping Li, “Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2,” Chemico-Biological Interactions, 2018. View at Publisher · View at Google Scholar
  • Jin Zeng, Yu-juan Fan, Bo Tan, Hui-zong Su, Yue Li, Lin-lin Zhang, Jian Jiang, and Fu-rong Qiu, “Charactering the metabolism of cryptotanshinone by human P450 enzymes and uridine diphosphate glucuronosyltransferases in vitro,” Acta Pharmacologica Sinica, 2018. View at Publisher · View at Google Scholar