Research Article
Relationship between EGF, TGFA, and EGFR Gene Polymorphisms and Traditional Chinese Medicine ZHENG in Gastric Cancer
Table 4
Relationship between EGFR gene polymorphisms and the ZHENG of GC.
| SNPs | Genotype | Type of ZHENG (%) | | | SSD | YDSH | DQY | DQB | DLS | DHT | SPM | OBS | Other |
| rs6965469 | CC | 40 (65.6) | 39 (67.2) | 13 (56.5) | 37 (77.1) | 23 (54.8) | 37 (68.5) | 25 (62.5) | 22 (62.9) | 13 (59.1) | 11.629 | 0.769 | TC | 19 (31.1) | 17 (29.3) | 10 (43.5) | 10 (20.8) | 18 (42.9) | 17 (31.5) | 14 (35.0) | 13 (37.1) | 9 (40.9) | — | — | TT | 2 (3.3) | 2 (3.4) | 0 (0.0) | 1 (2.1) | 1 (2.4) | 0 (0.0) | 1 (2.5) | 0 (0.0) | 0 (0.0) | — | — | TC/TT | 21 (34.4) | 19 (32.8) | 10 (43.5) | 11 (22.9) | 19 (45.2) | 17 (31.5) | 15 (37.5) | 13 (37.1) | 9 (40.9) | 6.692 | 0.570 | C allele | 99 (81.1) | 95 (81.9) | 36 (78.3) | 84 (87.5) | 64 (76.2) | 91 (84.3) | 64 (80.0) | 57 (81.4) | 35 (79.5) | 4.996 | 0.758 | T allele | 23 (18.9) | 21 (18.1) | 10 (21.7) | 12 (12.5) | 20 (23.8) | 17 (15.7) | 16 (20.0) | 13 (18.6) | 9 (20.5) | — | — |
| rs17337023 | AA | 24 (40.7) | 12 (20.7) | 9 (39.1) | 16 (33.3) | 14 (32.6) | 21 (38.9) | 11 (27.5) | 10 (28.6) | 6 (27.3) | 18.596 | 0.290 | TA | 18 (30.5) | 35 (60.3) | 9 (39.1) | 24 (50.0) | 19 (44.2) | 23 (42.6) | 20 (50.0) | 16 (45.7) | 7 (31.8) | — | — | TT | 17 (28.8) | 11 (19.0) | 5 (21.7) | 8 (16.7) | 10 (23.3) | 10 (18.5) | 9 (22.5) | 9 (25.7) | 9 (40.9) | — | — | TA/TT | 35 (59.3) | 46 (79.3) | 14 (60.9) | 32 (66.7) | 29 (67.4) | 33 (61.1) | 29 (72.5) | 25 (71.4) | 16 (72.7) | 7.966 | 0.437 | A allele | 66 (55.9) | 59 (50.9) | 27 (58.7) | 56 (58.3) | 47 (54.7) | 65 (60.2) | 42 (52.5) | 36 (51.4) | 19 (43.2) | 5.689 | 0.682 | T allele | 52 (44.1) | 57 (49.1) | 19 (41.3) | 40 (41.7) | 39 (45.3) | 43 (39.8) | 38 (47.5) | 34 (48.6) | 25 (56.8) | — | — |
| rs2227983 | AA | 19 (32.2) | 12 (21.1) | 8 (34.8) | 13 (28.3) | 14 (35.0) | 19 (36.5) | 11 (28.9) | 9 (25.7) | 4 (19.0) | 6.997 | 0.973 | GA | 27 (45.8) | 32 (56.1) | 11 (47.8) | 24 (52.2) | 20 (50.0) | 24 (46.2) | 20 (52.6) | 17 (48.6) | 12 (57.1) | — | — | GG | 13 (22.0) | 13 (22.8) | 4 (17.4) | 9 (19.6) | 6 (15.0) | 9 (17.3) | 7 (18.4) | 9 (25.7) | 5 (23.8) | — | — | GA/GG | 40 (67.8) | 45 (78.9) | 15 (65.2) | 33 (71.7) | 26 (65.0) | 33 (63.5) | 27 (71.1) | 26 (74.3) | 17 (81.0) | 5.687 | 0.682 | A allele | 65 (55.1) | 56 (49.1) | 27 (58.7) | 50 (54.3) | 48 (60.0) | 62 (59.6) | 42 (55.3) | 35 (50.0) | 20 (47.6) | 5.137 | 0.743 | G allele | 53 (44.9) | 58 (50.9) | 19 (41.3) | 42 (45.7) | 32 (40.0) | 42 (40.4) | 34 (44.7) | 35 (50.0) | 22 (52.4) | — | — |
| rs1140475 | CC | 60 (98.4) | 54 (93.1) | 18 (78.3) | 41 (85.4) | 41 (97.6) | 48 (88.9) | 36 (90.0) | 32 (91.4) | 21 (95.5) | 14.620 | 0.067 | TC | 1 (1.6) | 4 (6.9) | 5 (21.7) | 7 (14.6) | 1 (2.4) | 6 (11.1) | 4 (10.0) | 3 (8.6) | 1 (4.5) | — | — | C allele | 121 (99.2) | 112 (96.6) | 41 (89.1) | 89 (92.7) | 83 (98.8) | 102 (94.4) | 76 (95.0) | 67 (95.7) | 43 (97.7) | 13.983 | 0.082 | T allele | 1 (0.8) | 4 (3.4) | 5 (10.9) | 7 (7.3) | 1 (1.2) | 6 (5.6) | 4 (5.0) | 3 (4.3) | 1 (2.3) | — | — |
| rs884225 | GG | 19 (31.1) | 23 (39.7) | 5 (21.7) | 7 (14.6) | 14 (32.6) | 18 (33.3) | 11 (27.5) | 13 (37.1) | 9 (40.9) | 29.163 | 0.023 | GA | 27 (44.3) | 29 (50.0) | 8 (34.8) | 23 (47.9) | 18 (41.9) | 19 (35.2) | 24 (60.0) | 17 (48.6) | 9 (40.9) | — | — | AA | 15 (24.6) | 6 (10.3) | 10 (43.5) | 18 (37.5) | 11 (25.6) | 17 (31.5) | 5 (12.5) | 5 (14.3) | 4 (18.2) | — | — | GA/AA | 42 (68.9) | 35 (60.3) | 18 (78.3) | 41 (85.4) | 29 (67.4) | 36 (66.7) | 29 (72.5) | 22 (62.9) | 13 (59.1) | 11.047 | 0.199 | G allele | 65 (53.3) | 75 (64.7) | 18 (39.1) | 37 (38.5) | 46 (53.5) | 55 (50.9) | 46 (57.5) | 43 (61.4) | 27 (61.4) | 21.924 | 0.005 | A allele | 57 (46.7) | 41 (35.3) | 28 (60.9) | 59 (61.5) | 40 (46.5) | 53 (49.1) | 34 (42.5) | 27 (38.6) | 17 (38.6) | — | — |
| rs884904 | AA | 19 (31.1) | 23 (39.7) | 5 (21.7) | 7 (14.6) | 14 (32.6) | 17 (31.5) | 11 (27.5) | 13 (37.1) | 9 (40.9) | 25.536 | 0.061 | GA | 28 (45.9) | 27 (46.6) | 8 (34.8) | 24 (50.0) | 18 (41.9) | 20 (37.0) | 24 (60.0) | 17 (48.6) | 9 (40.9) | — | — | GG | 14 (23.0) | 8 (13.8) | 10 (43.5) | 17 (35.4) | 11 (25.6) | 17 (31.5) | 5 (12.5) | 5 (14.3) | 4 (18.2) | — | — | GA/GG | 42 (68.9) | 35 (60.3) | 18 (78.3) | 41 (85.4) | 29 (67.4) | 37 (68.5) | 29 (72.5) | 22 (62.9) | 13 (59.1) | 10.953 | 0.204 | A allele | 66 (54.1) | 73 (62.9) | 18 (39.1) | 38 (39.6) | 46 (53.5) | 54 (50.0) | 46 (57.5) | 43 (61.4) | 27 (61.4) | 19.366 | 0.013 | G allele | 56 (45.9) | 43 (37.1) | 28 (60.9) | 58 (60.4) | 40 (46.5) | 54 (50.0) | 34 (42.5) | 27 (38.6) | 17 (38.6) | — | — |
| rs763317 | GG | 37 (61.7) | 36 (62.1) | 13 (56.5) | 36 (75.0) | 20 (46.5) | 34 (63.0) | 22 (55.0) | 22 (62.9) | 14 (63.6) | 12.275 | 0.725 | GA | 21 (35.0) | 20 (34.5) | 9 (39.1) | 10 (20.8) | 21 (48.8) | 20 (37.0) | 16 (40.0) | 12 (34.3) | 8 (36.4) | — | — | AA | 2 (3.3) | 2 (3.4) | 1 (4.3) | 2 (4.2) | 2 (4.7) | 0 (0.0) | 2 (5.0) | 1 (2.9) | 0 (0.0) | — | — | GA/AA | 23 (38.3) | 22 (37.9) | 10 (43.5) | 12 (25.0) | 23 (53.5) | 20 (37.0) | 18 (45.0) | 13 (37.1) | 8 (36.4) | 8.796 | 0.360 | G allele | 95 (79.2) | 92 (79.3) | 35 (76.1) | 82 (85.4) | 61 (70.9) | 88 (81.5) | 60 (75.0) | 56 (80.0) | 36 (81.8) | 7.423 | 0.492 | A allele | 25 (20.8) | 24 (20.7) | 11 (23.9) | 14 (14.6) | 25 (29.1) | 20 (18.5) | 20 (25.0) | 14 (20.0) | 8 (18.2) | — | — |
| rs2293347 | GG | 28 (47.5) | 37 (64.9) | 10 (43.5) | 21 (45.7) | 23 (54.8) | 28 (52.8) | 22 (56.4) | 21 (61.8) | 13 (61.9) | 17.979 | 0.325 | GA | 26 (44.1) | 19 (33.3) | 10 (43.5) | 22 (47.8) | 13 (31.0) | 17 (32.1) | 16 (41.0) | 11 (32.4) | 6 (28.6) | — | — | AA | 5 (8.5) | 1 (1.8) | 3 (13.0) | 3 (6.5) | 6 (14.3) | 8 (15.1) | 1 (2.6) | 2 (5.9) | 2 (9.5) | — | — | GA/AA | 31 (52.5) | 20 (35.1) | 13 (56.5) | 25 (54.3) | 19 (45.2) | 25 (47.2) | 17 (43.6) | 13 (38.2) | 8 (38.1) | 7.544 | 0.479 | G allele | 82 (69.5) | 93 (81.6) | 30 (65.2) | 64 (69.6) | 59 (70.2) | 73 (68.9) | 60 (76.9) | 53 (77.9) | 32 (76.2) | 9.868 | 0.274 | A allele | 36 (30.5) | 21 (18.4) | 16 (34.8) | 28 (30.4) | 25 (29.8) | 33 (31.1) | 18 (23.1) | 15 (22.1) | 10 (23.8) | — | — |
| rs2072454 | CC | 20 (32.8) | 14 (24.1) | 10 (43.5) | 24 (50.0) | 13 (30.2) | 20 (37.0) | 12 (30.0) | 12 (34.3) | 5 (22.7) | 15.446 | 0.492 | TC | 27 (44.3) | 31 (53.4) | 8 (34.8) | 19 (39.6) | 21 (48.8) | 24 (44.4) | 22 (55.0) | 18 (51.4) | 10 (45.5) | — | — | TT | 14 (23.0) | 13 (22.4) | 5 (21.7) | 5 (10.4) | 9 (20.9) | 10 (18.5) | 6 (15.0) | 5 (14.3) | 7 (31.8) | — | — | TC/TT | 41 (67.2) | 44 (75.9) | 13 (56.5) | 24 (50.0) | 30 (69.8) | 34 (63.0) | 28 (70.0) | 23 (65.7) | 17 (77.3) | 10.996 | 0.202 | C allele | 67 (54.9) | 59 (50.9) | 28 (60.9) | 67 (69.8) | 47 (54.7) | 64 (59.3) | 46 (57.5) | 42 (60.0) | 20 (45.5) | 11.759 | 0.162 | T allele | 55 (45.1) | 57 (49.1) | 18 (39.1) | 29 (30.2) | 39 (45.3) | 44 (40.7) | 34 (42.5) | 28 (40.0) | 24 (54.5) | — | — |
| rs1050171 | GG | 46 (79.3) | 42 (76.4) | 16 (76.2) | 27 (65.9) | 31 (73.8) | 37 (69.8) | 27 (71.1) | 27 (77.1) | 16 (72.7) | 6.461 | 0.982 | GA | 12 (20.7) | 10 (18.2) | 4 (19.0) | 12 (29.3) | 10 (23.8) | 14 (26.4) | 10 (26.3) | 7 (20.0) | 5 (22.7) | — | — | AA | 0 (0.0) | 3 (5.5) | 1 (4.8) | 2 (4.9) | 1 (2.4) | 2 (3.8) | 1 (2.6) | 1 (2.9) | 1 (4.5) | — | — | GA/AA | 12 (20.7) | 13 (23.6) | 5 (23.8) | 14 (34.1) | 11 (26.2) | 16 (30.2) | 11 (28.9) | 8 (22.9) | 6 (27.3) | 3.288 | 0.915 | G allele | 104 (89.7) | 94 (85.5) | 36 (85.7) | 66 (80.5) | 72 (85.7) | 88 (83.0) | 64 (84.2) | 61 (87.1) | 37 (84.1) | 4.015 | 0.856 | A allele | 12 (10.3) | 16 (14.5) | 6 (14.3) | 16 (19.5) | 12 (14.3) | 18 (17.0) | 12 (15.8) | 9 (12.9) | 7 (15.9) | — | — |
|
|