Table 4: Relationship between EGFR gene polymorphisms and the ZHENG of GC.

SNPsGenotypeType of ZHENG (%)
SSDYDSHDQYDQBDLSDHTSPMOBSOther

rs6965469CC40 (65.6)39 (67.2)13 (56.5)37 (77.1)23 (54.8)37 (68.5)25 (62.5)22 (62.9)13 (59.1)11.6290.769
TC19 (31.1)17 (29.3)10 (43.5)10 (20.8)18 (42.9)17 (31.5)14 (35.0)13 (37.1)9 (40.9)
TT2 (3.3)2 (3.4)0 (0.0)1 (2.1)1 (2.4)0 (0.0)1 (2.5)0 (0.0)0 (0.0)
TC/TT21 (34.4)19 (32.8)10 (43.5)11 (22.9)19 (45.2)17 (31.5)15 (37.5)13 (37.1)9 (40.9)6.6920.570
C allele99 (81.1)95 (81.9)36 (78.3)84 (87.5)64 (76.2)91 (84.3)64 (80.0)57 (81.4)35 (79.5)4.9960.758
T allele23 (18.9)21 (18.1)10 (21.7)12 (12.5)20 (23.8)17 (15.7)16 (20.0)13 (18.6)9 (20.5)

rs17337023AA24 (40.7)12 (20.7)9 (39.1)16 (33.3)14 (32.6)21 (38.9)11 (27.5)10 (28.6)6 (27.3)18.5960.290
TA18 (30.5)35 (60.3)9 (39.1)24 (50.0)19 (44.2)23 (42.6)20 (50.0)16 (45.7)7 (31.8)
TT17 (28.8)11 (19.0)5 (21.7)8 (16.7)10 (23.3)10 (18.5)9 (22.5)9 (25.7)9 (40.9)
TA/TT35 (59.3)46 (79.3)14 (60.9)32 (66.7)29 (67.4)33 (61.1)29 (72.5)25 (71.4)16 (72.7)7.9660.437
A allele66 (55.9)59 (50.9)27 (58.7)56 (58.3)47 (54.7)65 (60.2)42 (52.5)36 (51.4)19 (43.2)5.6890.682
T allele52 (44.1)57 (49.1)19 (41.3)40 (41.7)39 (45.3)43 (39.8)38 (47.5)34 (48.6)25 (56.8)

rs2227983AA19 (32.2)12 (21.1)8 (34.8)13 (28.3)14 (35.0)19 (36.5)11 (28.9)9 (25.7)4 (19.0)6.9970.973
GA27 (45.8)32 (56.1)11 (47.8)24 (52.2)20 (50.0)24 (46.2)20 (52.6)17 (48.6)12 (57.1)
GG13 (22.0)13 (22.8)4 (17.4)9 (19.6)6 (15.0)9 (17.3)7 (18.4)9 (25.7)5 (23.8)
GA/GG40 (67.8)45 (78.9)15 (65.2)33 (71.7)26 (65.0)33 (63.5)27 (71.1)26 (74.3)17 (81.0)5.6870.682
A allele65 (55.1)56 (49.1)27 (58.7)50 (54.3)48 (60.0)62 (59.6)42 (55.3)35 (50.0)20 (47.6)5.1370.743
G allele53 (44.9)58 (50.9)19 (41.3)42 (45.7)32 (40.0)42 (40.4)34 (44.7)35 (50.0)22 (52.4)

rs1140475CC60 (98.4)54 (93.1)18 (78.3)41 (85.4)41 (97.6)48 (88.9)36 (90.0)32 (91.4)21 (95.5)14.6200.067
TC1 (1.6)4 (6.9)5 (21.7)7 (14.6)1 (2.4)6 (11.1)4 (10.0)3 (8.6)1 (4.5)
C allele121 (99.2)112 (96.6)41 (89.1)89 (92.7)83 (98.8)102 (94.4)76 (95.0)67 (95.7)43 (97.7)13.9830.082
T allele1 (0.8)4 (3.4)5 (10.9)7 (7.3)1 (1.2)6 (5.6)4 (5.0)3 (4.3)1 (2.3)

rs884225GG19 (31.1)23 (39.7)5 (21.7)7 (14.6)14 (32.6)18 (33.3)11 (27.5)13 (37.1)9 (40.9)29.1630.023
GA27 (44.3)29 (50.0)8 (34.8)23 (47.9)18 (41.9)19 (35.2)24 (60.0)17 (48.6)9 (40.9)
AA15 (24.6)6 (10.3)10 (43.5)18 (37.5)11 (25.6)17 (31.5)5 (12.5)5 (14.3)4 (18.2)
GA/AA42 (68.9)35 (60.3)18 (78.3)41 (85.4)29 (67.4)36 (66.7)29 (72.5)22 (62.9)13 (59.1)11.0470.199
G allele65 (53.3)75 (64.7)18 (39.1)37 (38.5)46 (53.5)55 (50.9)46 (57.5)43 (61.4)27 (61.4)21.9240.005
A allele57 (46.7)41 (35.3)28 (60.9)59 (61.5)40 (46.5)53 (49.1)34 (42.5)27 (38.6)17 (38.6)

rs884904AA19 (31.1)23 (39.7)5 (21.7)7 (14.6)14 (32.6)17 (31.5)11 (27.5)13 (37.1)9 (40.9)25.5360.061
GA28 (45.9)27 (46.6)8 (34.8)24 (50.0)18 (41.9)20 (37.0)24 (60.0)17 (48.6)9 (40.9)
GG14 (23.0)8 (13.8)10 (43.5)17 (35.4)11 (25.6)17 (31.5)5 (12.5)5 (14.3)4 (18.2)
GA/GG42 (68.9)35 (60.3)18 (78.3)41 (85.4)29 (67.4)37 (68.5)29 (72.5)22 (62.9)13 (59.1)10.9530.204
A allele66 (54.1)73 (62.9)18 (39.1)38 (39.6)46 (53.5)54 (50.0)46 (57.5)43 (61.4)27 (61.4)19.3660.013
G allele56 (45.9)43 (37.1)28 (60.9)58 (60.4)40 (46.5)54 (50.0)34 (42.5)27 (38.6)17 (38.6)

rs763317GG37 (61.7)36 (62.1)13 (56.5)36 (75.0)20 (46.5)34 (63.0)22 (55.0)22 (62.9)14 (63.6)12.2750.725
GA21 (35.0)20 (34.5)9 (39.1)10 (20.8)21 (48.8)20 (37.0)16 (40.0)12 (34.3)8 (36.4)
AA2 (3.3)2 (3.4)1 (4.3)2 (4.2)2 (4.7)0 (0.0)2 (5.0)1 (2.9)0 (0.0)
GA/AA23 (38.3)22 (37.9)10 (43.5)12 (25.0)23 (53.5)20 (37.0)18 (45.0)13 (37.1)8 (36.4)8.7960.360
G allele95 (79.2)92 (79.3)35 (76.1)82 (85.4)61 (70.9)88 (81.5)60 (75.0)56 (80.0)36 (81.8)7.4230.492
A allele25 (20.8)24 (20.7)11 (23.9)14 (14.6)25 (29.1)20 (18.5)20 (25.0)14 (20.0)8 (18.2)

rs2293347GG28 (47.5)37 (64.9)10 (43.5)21 (45.7)23 (54.8)28 (52.8)22 (56.4)21 (61.8)13 (61.9)17.9790.325
GA26 (44.1)19 (33.3)10 (43.5)22 (47.8)13 (31.0)17 (32.1)16 (41.0)11 (32.4)6 (28.6)
AA5 (8.5)1 (1.8)3 (13.0)3 (6.5)6 (14.3)8 (15.1)1 (2.6)2 (5.9)2 (9.5)
GA/AA31 (52.5)20 (35.1)13 (56.5)25 (54.3)19 (45.2)25 (47.2)17 (43.6)13 (38.2)8 (38.1)7.5440.479
G allele82 (69.5)93 (81.6)30 (65.2)64 (69.6)59 (70.2)73 (68.9)60 (76.9)53 (77.9)32 (76.2)9.8680.274
A allele36 (30.5)21 (18.4)16 (34.8)28 (30.4)25 (29.8)33 (31.1)18 (23.1)15 (22.1)10 (23.8)

rs2072454CC20 (32.8)14 (24.1)10 (43.5)24 (50.0)13 (30.2)20 (37.0)12 (30.0)12 (34.3)5 (22.7)15.4460.492
TC27 (44.3)31 (53.4)8 (34.8)19 (39.6)21 (48.8)24 (44.4)22 (55.0)18 (51.4)10 (45.5)
TT14 (23.0)13 (22.4)5 (21.7)5 (10.4)9 (20.9)10 (18.5)6 (15.0)5 (14.3)7 (31.8)
TC/TT41 (67.2)44 (75.9)13 (56.5)24 (50.0)30 (69.8)34 (63.0)28 (70.0)23 (65.7)17 (77.3)10.9960.202
C allele67 (54.9)59 (50.9)28 (60.9)67 (69.8)47 (54.7)64 (59.3)46 (57.5)42 (60.0)20 (45.5)11.7590.162
T allele55 (45.1)57 (49.1)18 (39.1)29 (30.2)39 (45.3)44 (40.7)34 (42.5)28 (40.0)24 (54.5)

rs1050171GG46 (79.3)42 (76.4)16 (76.2)27 (65.9)31 (73.8)37 (69.8)27 (71.1)27 (77.1)16 (72.7)6.4610.982
GA12 (20.7)10 (18.2)4 (19.0)12 (29.3)10 (23.8)14 (26.4)10 (26.3)7 (20.0)5 (22.7)
AA0 (0.0)3 (5.5)1 (4.8)2 (4.9)1 (2.4)2 (3.8)1 (2.6)1 (2.9)1 (4.5)
GA/AA12 (20.7)13 (23.6)5 (23.8)14 (34.1)11 (26.2)16 (30.2)11 (28.9)8 (22.9)6 (27.3)3.2880.915
G allele104 (89.7)94 (85.5)36 (85.7)66 (80.5)72 (85.7)88 (83.0)64 (84.2)61 (87.1)37 (84.1)4.0150.856
A allele12 (10.3)16 (14.5)6 (14.3)16 (19.5)12 (14.3)18 (17.0)12 (15.8)9 (12.9)7 (15.9)