A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula
Figure 2
(a), (b), (c), and (d) Top 10 enriched pathways and associated herbal compounds corresponding to module 1, 2, 4, and 5, respectively. The herbal compounds are ranked by Promiscuity Index (PI), which is defined as the number of targets connected to a given compound by the preserved CPIs in a detected module. Note that only compounds with PI greater than zero are listed in this figure. The enriched pathways are ranked by the values calculated in MetaDrug. The circled numbers in brackets after pathway name indicate the major category that pathway belongs to. For example, “ESR1 regulation of G1/S transition” belongs to category 1 and 3, that is, cell cycle and development. The category knowledge is curated from the classification tree of GeneGo pathways in MetaDrug. All pathways in this figure are significant with values lower than 0.001.
