A Module Analysis Approach to Investigate Molecular Mechanism of TCM Formula: A Trial on Shu-feng-jie-du Formula

Table 2

Topological properties of the 2-HN for SHU formula and its three subnetworks.

Property		CSN	PSN	GSN	2-HN
Node	Compounds	171	50	0	171
	Proteins	0	238	238	238
Edge	CCIs	481	0	0	481
	CPIs	0	1101	0	1101
	PPIs	0	0	718	718
Connected components		34	1	57	1
Isolated nodes		17	0	55	0
Clustering coefficient		0.662	0.0	0.198	0.414
Network density		0.033	0.027	0.025	0.028
Network heterogeneity		0.664	2.531	1.287	1.588

∗CCI is short for compound-compound interaction, CPI is compound-protein interaction, and PPI is protein-protein interaction. CSN represents the chemical subnetwork of the 2-HN for SHU formula, PSN the pharmacological subnetwork, and GSN the genomic subnetwork.
∗All the topological properties were calculated using Cytoscape 2.8 [32].