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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 734824, 7 pages
Research Article

Anti-Inflammatory, Anticholinesterase, and Antioxidant Potential of Scopoletin Isolated from Canarium patentinervium Miq. (Burseraceae Kunth)

Center for Natural and Medicinal Products Research, School of Pharmacy, Faculty of Science, University of Nottingham (Malaysia Campus), Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan, Malaysia

Received 13 March 2013; Accepted 14 June 2013

Academic Editor: Mohd Roslan Sulaiman

Copyright © 2013 R. Mogana et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Bioassay guided fractionation of an ethanol extract of leaves of Canarium patentinervium Miq. (Burseraceae Kunth.) led to the isolation of scopoletin. The structure of this coumarin was elucidated based on spectroscopic methods including nuclear magnetic resonance (NMR-1D and 2D) and mass spectrometry. Scopoletin inhibited the enzymatic activity of 5-lipoxygenase and acetyl cholinesterase with an IC50 equal to μM and  mM, respectively, and confronted oxidation in the ABTS, DPPH, FRAP, and β-carotene bleaching assay with EC50 values equal to μM,  mM,  mM and  mM, respectively. Given the aforementioned evidence, it is tempting to speculate that scopoletin represents an exciting scaffold from which to develop leads for treatment of neurodegenerative diseases.