Differences of Excess and Deficiency Zheng in Patients with Chronic Hepatitis B by Urinary Metabonomics

Table 6

Disturbed pathways of EZ and DZ compared to WZ group.

Pathway	𝑃-val; EZ versus WZ	𝑃-val; DZ versus WZ	Class	Annotation
ABC transporters	<0.0001	<0.0001	Environmental information processing	Two ZHENGs in common
Pentose phosphate pathway	<0.0001	<0.0001	Carbohydrate metabolism	Two ZHENGs in common
Aminoacyl-tRNA biosynthesis	0.003	0.006	Carbohydrate metabolism	Two ZHENGs in common
Galactose metabolism	0.012	0.009	Carbohydrate metabolism	Two ZHENGs in common
Starch and sucrose metabolism	0.018	0.015	Carbohydrate metabolism	Two ZHENGs in common
Pentose and glucuronate interconversions	0.020	0.029	Genetic information processing	Two ZHENGs in common
Ascorbate and aldarate metabolism	<0.0001	>0.05	Carbohydrate metabolism	Specific for EZ
Glycine, serine, and threonine metabolism	0.017	>0.05	Amino acid metabolism	Specific for EZ
Alanine, aspartate, and glutamate metabolism	>0.05	0.003	Amino acid metabolism	Specific for DZ
Amino sugar and nucleotide sugar metabolism	>0.05	0.003	Carbohydrate metabolism	Specific for DZ
Glycolysis/gluconeogenesis	>0.05	0.005	Carbohydrate metabolism	Specific for DZ
Purine metabolism	>0.05	0.042	Nucleotide metabolism	Specific for DZ

𝑃-val: the statistical significance of each pathway obtained from analysis of MBRole.
Class: categorization of each pathway obtained from KEGG.