Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses

Table 6

Plaque reduction of influenza A virus by flavonoids of S. baicalensis.

Flavonoids	CC50 (μM)	Plaque inhibition IC50 values (μM)		Therapeutic index
	MDCK cells	Seasonal 2007 H1N1	Pandemic 2009 H1N1	Seasonal 2007 H1N1	Pandemic 2009 H1N1
Baicalein	0.045 ± 0.088	0.018 ± 0.062	0.020 ± 0.077	2.5	2.3
Baicalin	0.015	>0.01	>0.01
Apigenin	218.34 ± 0.11	119.61 ± 0.032	94.16 ± 0.047	1.8	2.3
Chrysin	266.66 ± 0.077	>200	>200