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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 758273, 8 pages
Research Article

The Evaluation of the Body Weight Lowering Effects of Herbal Extract THI on Exercising Healthy Overweight Humans: A Randomized Double-Blind, Placebo-Controlled Trial

1Department of Family Medicine, College of Medicine, Chung-Ang University Hospital, Seoul 156-755, Republic of Korea
2Department of Microbiology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea
3Department of Life Science, Sookmyung Women’s University, Seoul 140-742, Republic of Korea

Received 9 December 2012; Revised 14 September 2013; Accepted 14 September 2013

Academic Editor: Menaka C. Thounaojam

Copyright © 2013 Soo Hyun Cho et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We investigated the effects of herbal extracts, a mixture of Scutellariae Radix and Platycodi Radix containing the active ingredients Baicalin and Saponin (target herbal ingredient (THI)), on lowering body weight. The present study was a prospective, randomized, double-blind, and placebo-controlled trial carried out at the outpatient department of a hospital over a period of 2 months. Group 1 patients ( ) received THI, and group 2 patients ( ) received placebo three times a day before meals. Weight, waist circumference, BMI, total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol, and glucose were measured at baseline and again at the 2nd month. For safety evaluation, various hematological and biochemical parameters were assessed. Values of mean change of weight in the THI-treated group were  kg and in the placebo-treated group were  kg, respectively. The difference in mean change of weight in the THI-treated group compared with that in the placebo-treated group was statistically significant ( ). The incidence of subjective and objective adverse drug reactions was insignificant ( ). THI was statistically significant in its effectiveness on the weight loss.