Salvianolic Acid B Prevents Arsenic Trioxide-Induced Cardiotoxicity In Vivo and Enhances Its Anticancer Activity In Vitro

Figure 6

Effects of Sal B and ATO treatment on apoptosis-related proteins in vitro. Western blotting was performed on HepG2 (a) and HeLa (b) cells treated with ATO, Sal B, or both (4 μM ATO, 10 μM Sal B) for 48 h. The activation of caspase-3 is reflected by the reduced amount of procaspase-3, and the activation of PARP is reflected by the amount of the cleaved PARP. β-actin served as an internal control. The data are expressed as means ± SD from three independent experiments. *𝑃<0.05 versus control; **𝑃<0.01 versus control; ^#𝑃<0.05 versus ATO-treated cells; ^##𝑃<0.01 versus ATO-treated cells.

(a)

(b)