Citrus bergamia Risso Elevates Intracellular Ca²⁺ in Human Vascular Endothelial Cells due to Release of Ca²⁺ from Primary Intracellular Stores

Figure 2

Application of BEO increased [Ca²⁺]_i in a concentration-dependent manner (a). Summary data describing the concentration-response relationship for BEO effects on [Ca²⁺]_i (b). Data are means ± SEMs. Applications of BEO or drugs are indicated by upper or bottom lines. Effects of BEO on [Ca²⁺]_i in human vascular endothelial cells. In the presence of extracellular Ca²⁺, application of BEO (0.1% v/v) induced an increase in [Ca²⁺]_i that was significantly inhibited by La³⁺ (1 μM) ((c), (d)). *𝑃<.05 compared to the BEO group; 𝑛 = 10~13 cells/group.

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