Beneficial Effects of an 8-Week, Very Low Carbohydrate Diet Intervention on Obese Subjects
Table 2
Effects of fat distribution, glucose homeostasis, and insulin sensitivity in obese subjects after a VLCD intervention.
Baseline
Week 4
Week 8
Change from baseline to week 8
P
SFA, cm2
348.0 ± 16.7
299.4 ± 16.2
264.0 ± 16.4
−66.5 ± 7.9
<0.0001
VFA, cm2
113.9 ± 5.8
96.6 ± 4.9
79.8 ± 3.7
−35.3 ± 3.9
<0.0001
Liver fat, %
22.3 ± 2.7
13.5 ± 3.2
6.5 ± 1.4
−16.4 ± 2.4
<0.0001
SMMP, %
33.7 ± 0.9
34.1 ± 1.3
36.7 ± 0.8
1.7 ± 0.2
<0.0001
FMP, %
37.2 ± 1.4
38.9 ± 2.0
34.3 ± 1.3
−3.0 ± 0.4
<0.0001
FPG, mmol/L
5.3 ± 0.1
5.0 ± 0.1
5.2 ± 0.1
−0.07 ± 0.15
0.001
2h PG, mmol/L
7.5 ± 0.3
—
6.9 ± 0.3
−0.59 ± 0.31
0.061
FINS, μU/mL
22.5 ± 4.0
10.2 ± 0.8
11.8 ± 1.4
−11.5 ± 4.3
0.003
2h INS, μU/mL
134.2 ± 11.3
—
71.1 ± 8.2
−57.2 ± 11.3
<0.0001
HOMA IR
6.1 ± 1.5
2.3 ± 0.2
2.8 ± 0.4
−3.6 ± 1.7
0.006
HOMA β
235.7 ± 21.6
140.3 ± 11.4
136.2 ± 12.1
−104.8 ± 18.3
<0.0001
WBISI
67.0 ± 6.9
—
123.7 ± 12.8
54.2 ± 13.9
<0.0001
Data are presented as mean ± standard error (SE). SFA: subcutaneous fat area; VFA: visceral fat area; SMMP: skeletal muscle mass percentage of whole body weight; FMP: fat mass percentage of whole body weight;. FPG: fasting plasma glucose; 2hPG: 2h postprandial glucose; FINS: fasting insulin; WBISI: whole body insulin sensitivity index. P: changes of sequential data within experiments from baseline to week 8. Significant difference observed versus baseline: ; .