Research Article

Trans-β-Caryophyllene: An Effective Antileishmanial Compound Found in Commercial Copaiba Oil (Copaifera spp.)

Figure 4

Antileishmanial activity of β-caryophyllene (CAR). (a) Leishmania amazonensis promastigotes were treated with CAR at 50 μg/mL or with DMSO 0.5% (vehicle). The antipromastigote effect was measured by counting of viable parasites for five days. Results from two experiments are shown as the number of promastigotes ± SEM. . (b) Mouse peritoneal macrophages infected with Leishmania amazonensis amastigote were treated for 24 h with the indicated concentrations of CAR or 1 μg/mL AMB (amphotericin B), or 0.5% of DMSO (vehicle). Results from five experiments in triplicates are shown as % killing ± SEM in relation to the untreated control. in relation to DMSO.
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