Exploring Antiurolithic Effects of Gokshuradi Polyherbal Ayurvedic Formulation in Ethylene-Glycol-Induced Urolithic Rats
Table 2
Effect of GPAE and standard drug on 24 h urinary biochemical parameters.
Parameters
Control
Urolithic
GPAE 50 mg/kg
GPAE 100 mg
Standard drug 100 mg/kg
Change in body weight (%)
11.88 ± 1.53
−4.78** ± 1.08
2.32**, ## ± 1.45
8.86## ± 2.06
5.43**, ## ± 1.23
Water intake mL/24 h
6.22 ± 0.39
24.35** ± 7.23
14.3 ± 2.32
8.45# ± 1.17
11.2 ± 2.21
Urine vol. (mL)
5.82 ± 0.45
26.25** ± 6.76
16.43* ± 3.24
10.46*, # ± 1.26
13.65* ± 2.84
pH
6.38 ± 0.09
6.17 ± 0.16
6.27 ± 0.11
6.45 ± 0.14
6.32 ± 0.15
Oxalate (mg)
0.38 ± 0.10
2.12** ± 0.21
1.35** ± 0.25
0.68## ± 0.11
1.89** ± 0.18
Ca2+ (mg)
3.67 ± 0.24
1.84** ± 0.16
2.63* ± 0.29
3.16# ± 0.64
2.89* ± 0.41
Mg2+ (mg)
3.28 ± 0.32
2.67 ± 0.11
3.42 ± 0.24
3.76# ± 0.31
2.87 ± 0.32
Citrate (mg)
23.10 ± 1.21
18.5 ± 1.90
19.12 ± 2.63
19.31 ± 1.22
18.34 ± 2.54
IPa (mg)
6.26 ± 0.82
7.89 ± 1.25
7.57 ± 0.55
7.55 ± 0.75
7.34 ± 0.32
UAb (mg)
0.58 ± 0.17
1.23 ± 0.40
1.05 ± 0.25
0.83 ± 0.22
0.98 ± 0.22
Values given are mean ± S.E.M. (n = 6).
*
P < 0.05.
**
P < 0.01 versus control group.
#P < 0.05.
##P < 0.01 versus urolithic group.
aInorganic phosphate. bUric acid.
