Chinese Medicinal Formula (MHGWT) for Relieving Diabetic Neuropathic Pain: A Randomized, Double-Blind, Placebo-Controlled Trial

Table 3

Changes of scores of Short-Form McGill Pain Questionnaire after interventions.

Domains	Group, number		𝑃 value
	MHGWT group (𝑛=56)	Placebo group (𝑛=56)
Sensory
Baseline	7.30 ± 3.42	5.91 ± 3.77	0.04^∗
Time 2 − baseline	−1.93 ± 2.58	0.04 ± 3.04	0.001^∗∗
Time 3 − baseline	−3.36 ± 3.01	0.13 ± 3.06	<0.001^∗∗∗
Time 4 − baseline	−3.85 ± 3.20	−0.07 ± 3.36	<0.001^∗∗∗
Scheffe’s test for time effect	a > b > c, d
Affective
Baseline	2.22 ± 1.54	1.66 ± 1.75	0.08
Time 2 − baseline	−0.43 ± 1.52	0.43 ± 1.06	0.003^∗∗
Time 3 − baseline	−0.93 ± 1.60	0.26 ± 1.13	<0.001^∗∗∗
Time 4 − baseline	−1.07 ± 1.68	0.41 ± 1.26	<0.001^∗∗∗
Scheffe’s test for time effect	a > b, c, d; b > d
VAS
Baseline	4.98 ± 1.39	4.07 ± 1.53	0.002^∗∗
Time 2 − baseline	−1.55 ± 1.16	−0.04 ± 1.38	0.002^∗∗
Time 3 − baseline	−2.50 ± 1.61	−0.10 ± 1.56	<0.001^∗∗∗
Time 4 − baseline	−3.10 ± 1.69	−0.31 ± 1.61	<0.001^∗∗∗
Scheffe’s test for time effect	a > b > c > d
PPI
Baseline	2.52 ± 0.72	2.18 ± 0.69	0.01^∗∗
Time 2 − baseline	−0.45 ± 0.70	0.09 ± 0.75	<0.001^∗∗∗
Time 3 − baseline	−0.98 ± 0.72	−0.08 ± 0.78	<0.001^∗∗∗
Time 4 − baseline	−1.20 ± 0.75	−0.17 ± 0.89	<0.001^∗∗∗
Scheffe’s test for time effect	a > b > c, d
Total
Baseline	9.52 ± 4.17	7.57 ± 5.09	0.03^∗
Time 2 − baseline	−2.36 ± 3.62	0.47 ± 3.65	<0.001^∗∗∗
Time 3 − baseline	−4.29 ± 3.80	0.39 ± 3.45	<0.001^∗∗∗
Time 4 − baseline	−4.93 ± 4.27	0.34 ± 4.08	<0.001^∗∗∗
Scheffe’s test for time effect	a > b > c, d

Time 2 was in the end of 4 weeks, time 3 was in the end of 8 weeks, and time 4 was in the end of 12 weeks.
Data were presented as mean ± SD.
𝑃 values are calculated for the comparison between MHGWT and placebo groups by independent 𝑡-test.
^∗𝑃<0.05; ^∗∗𝑃<0.01; ^∗∗∗𝑃<0.001.
a: time 1; b: time 2; c: time 3; d: time 4.