In Vitro and In Vivo Evaluation of Polyherbal Formulation against Russell’s Viper and Cobra Venom and Screening of Bioactive Components by Docking Studies

Table 4

Effect of the aqueous extract of  AB, TI, and LA on venom-induced hemorrhage effects.

Group (𝑛=5)	Venom-induced hemorrhage; (MHD mean ± S.E.M)
	Vipera russelli venom	Naja naja venom
Control (0.5 mL saline p.o.)	10.32 ± 0.236	10.03 ± 0.320
AB (200 mg/kg p.o.)	7.27 ± 0.327**	4.32 ± 0.411**
TI (200 mg/kg p.o.)	8.77 ± 0.421*	7.49 ± 0.231**
LA (200 mg/kg p.o.)	4.96 ± 0.330**	6.06 ± 0.332**
Polyherbal formulation; (200 mg/kg p.o.)	5.42 ± 0.330**	6.38 ± 0.220**

All values are expressed as a mean ± SEM, 𝑛=6. One way analysis of variance (ANOVA) followed by multiple comparison Dunnett’s test. The minimum value of  𝑃<0.05 was considered significant. *𝑃<0.05, **𝑃<0.01,  compared to control group.