Table of Contents Author Guidelines Submit a Manuscript
Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 786528, 9 pages
http://dx.doi.org/10.1155/2013/786528
Research Article

Unexpected Nephrotoxicity in Male Ablactated Rats Induced by Cordyceps militaris: The Involvement of Oxidative Changes

Department of Pharmacy, Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu 210036, China

Received 29 October 2012; Revised 8 January 2013; Accepted 16 January 2013

Academic Editor: Wagner Vilegas

Copyright © 2013 Xiaowen Zhou and Yi Yao. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. X. Zhou, Z. Gong, Y. Su, J. Lin, and K. Tang, “Cordyceps fungi: natural products, pharmacological functions and developmental products,” Journal of Pharmacy and Pharmacology, vol. 61, no. 3, pp. 279–291, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. J. S. Baik, H. Y. Kwon, K. S. Kim, Y. K. Jeong, Y. S. Cho, and Y. C. Lee, “Cordycepin induces apoptosis in human neuroblastoma SK-N-BE(2)-C and melanoma SK-MEL-2 cells,” Indian Journal of Biochemistry & Biophysics, vol. 49, no. 2, pp. 86–91, 2012. View at Google Scholar
  3. E. S. Han, J. Y. Oh, and H. J. Park, “Cordyceps militaris extract suppresses dextran sodium sulfate-induced acute colitis in mice and production of inflammatory mediators from macrophages and mast cells,” Journal of Ethnopharmacology, vol. 134, no. 3, pp. 703–710, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. J. W. Jeong, C. Y. Jin, C. Park et al., “Inhibition of migration and invasion of LNCaP human prostate carcinoma cells by cordycepin through inactivation of Akt,” International Journal of Oncology, vol. 40, no. 5, pp. 1697–1704, 2012. View at Google Scholar
  5. B. Lin and S. Li, “Cordyceps as an herbal drug,” in Herbal Medicine: Biomolecular and Clinical Aspects, I. F. F. Benzie and S. Wachtel-Galor, Eds., chapter 5, CRC Press, Boca Raton, Fla, USA, 2nd edition, 2011. View at Google Scholar
  6. K. Feng, Y. Q. Yang, and S. P. Li, “Renggongchongcao,” in Pharmacological Activity-Based Quality Control of Chinese Herbs, S. P. Li and Y. T. Wang, Eds., pp. 155–178, Nova Science Publisher, New York, NY, USA, 2008. View at Google Scholar
  7. C. L. Cheng, K. J. Chen, P. H. Shih et al., “Chronic renal failure rats are highly sensitive to aristolochic acids, which are nephrotoxic and carcinogenic agents,” Cancer Letters, vol. 232, no. 2, pp. 236–242, 2006. View at Publisher · View at Google Scholar · View at Scopus
  8. C. R. D. Colson and M. E. De Broe, “Kidney injury from alternative medicines,” Advances in Chronic Kidney Disease, vol. 12, no. 3, pp. 261–275, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. F. D. Debelle, J. L. Vanherweghem, and J. L. Nortier, “Aristolochic acid nephropathy: a worldwide problem,” Kidney International, vol. 74, no. 2, pp. 158–169, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Scheuplein, G. Charnley, and M. Dourson, “Differential sensitivity of children and adults to chemical toxicity. I. Biological basis,” Regulatory Toxicology and Pharmacology, vol. 35, no. 3, pp. 429–447, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. V. Linares, V. Alonso, M. L. Albina et al., “Lipid peroxidation and antioxidant status in kidney and liver of rats treated with sulfasalazine,” Toxicology, vol. 256, no. 3, pp. 152–156, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. P. J. Hissin and R. Hilf, “A fluorometric method for determination of oxidized and reduced glutathione in tissues,” Analytical Biochemistry, vol. 74, no. 1, pp. 214–226, 1976. View at Google Scholar · View at Scopus
  13. D. Barrera, P. D. Maldonado, O. N. Medina-Campos, R. Hernández-Pando, M. E. Ibarra-Rubio, and J. Pedraza-Chaverri, “HO-1 induction attenuates renal damage and oxidative stress induced by K2Cr2O7,” Free Radical Biology and Medicine, vol. 35, no. 1, pp. 1390–1398, 2003. View at Publisher · View at Google Scholar · View at Scopus
  14. J. Pedraza-Chaverri, P. Yam-Canul, Y. I. Chirino, D. J. Sánchez-González, C. M. Martínez-Martínez, and C. Cruz, “Protective effects of garlic powder against potassium dichromate-induced oxidative stress and nephrotoxicity,” Food and Chemical Toxicology, vol. 46, no. 2, pp. 619–627, 2008. View at Google Scholar
  15. W. J. Yan, T. H. Li, Q. Y. Lin, B. Song, and Z. D. Jiang, “Safety assessment of Cordyceps guangdongensis,” Food and Chemical Toxicology, vol. 48, no. 11, pp. 3080–3084, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. R. R. M. Paterson, “Cordyceps—a traditional Chinese medicine and another fungal therapeutic biofactory?” Phytochemistry, vol. 69, no. 7, pp. 1469–1495, 2008. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Joy and C. K. K. Nair, “Amelioration of cisplatin induced nephrotoxicity in Swiss albino mice by Rubia cordifolia extract,” Journal of Cancer Research and Therapeutics, vol. 4, no. 3, pp. 111–115, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. K. Wojcikowski, L. Stevenson, D. Leach, H. Wohlmuth, and G. Gobe, “Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: a comparison using a sequential three-solvent extraction process,” Journal of Alternative and Complementary Medicine, vol. 13, no. 1, pp. 103–109, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Romeu, M. Mulero, M. Giralt et al., “Parameters related to oxygen free radicals in erythrocytes, plasma and epidermis of the hairless rat,” Life Sciences, vol. 71, no. 15, pp. 1739–1749, 2002. View at Google Scholar
  20. F. Golab, M. Kadkhodaee, J. Xu, and M. Soleimani, “Male susceptibility to hepatic damage in acute uremia in rats,” Urology, vol. 78, no. 1, pp. 232.e1–232.e6, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Ljubojević, C. M. Herak-Kramberger, Y. Hagos et al., “Rat renal cortical OAT1 and OAT3 exhibit gender differences determined by both androgen stimulation and estrogen inhibition,” American Journal of Physiology, vol. 287, no. 1, pp. F124–F138, 2004. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Sakemi, N. Ohtsuka, Y. Tomiyoshi, and F. Morito, “Sex difference in progression of adriamycin-induced nephropathy in rats,” American Journal of Nephrology, vol. 16, no. 6, pp. 540–547, 1996. View at Google Scholar · View at Scopus
  23. T. Ichimura, C. C. Hung, S. A. Yang, J. L. Stevens, and J. V. Bonventre, “Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury,” American Journal of Physiology, vol. 286, no. 3, pp. F552–F563, 2004. View at Google Scholar · View at Scopus
  24. E. T. Gatzidou, A. N. Zira, and S. E. Theocharis, “Toxicogenomics: a pivotal piece in the puzzle of toxicological research,” Journal of Applied Toxicology, vol. 27, no. 4, pp. 302–309, 2007. View at Publisher · View at Google Scholar · View at Scopus
  25. S. H. Sohn, S. C. Lee, S. Y. Hwang et al., “Effect of long-term administration of cordycepin from Cordyceps militaris on testicular function in middle-aged rats,” Planta Medica, vol. 78, no. 15, pp. 1620–1625, 2012. View at Google Scholar
  26. J. S. Zhu, G. M. Halpern, and K. Jones, “The scientific rediscovery of an ancient Chinese herbal medicine: cordyceps sinensis—part I,” Journal of Alternative and Complementary Medicine, vol. 4, no. 3, pp. 289–303, 1998. View at Google Scholar · View at Scopus
  27. J. H. Koh, J. M. Kim, U. J. Chang, and H. J. Suh, “Hypocholesterolemic effect of hot-water extract from mycelia of Cordyceps sinensis,” Biological and Pharmaceutical Bulletin, vol. 26, no. 1, pp. 84–87, 2003. View at Publisher · View at Google Scholar · View at Scopus
  28. Y. J. Niu, R. Y. Tao, Q. Liu et al., “Improvement on lipid metabolic disorder by 3-deoxyadenosine in high-fat-diet-induced fatty mice,” American Journal of Chinese Medicine, vol. 38, no. 6, pp. 1065–1075, 2010. View at Google Scholar
  29. J. Gao, Z. Q. Lian, P. Zhu, and H. B. Zhu, “Lipid-lowering effect of cordycepin (3-deoxyadenosine) from Cordyceps militaris on hyperlipidemic hamsters and rats,” Acta Pharmaceutica Sinica, vol. 46, no. 6, pp. 669–676, 2011. View at Google Scholar
  30. P. Guo, Q. Kai, J. Gao et al., “Cordycepin prevents hyperlipidemia in hamsters fed a high-fat diet via activation of AMP-activated protein kinase,” Journal of Pharmacological Sciences, vol. 113, no. 4, pp. 395–403, 2010. View at Publisher · View at Google Scholar · View at Scopus