Unexpected Nephrotoxicity in Male Ablactated Rats Induced by Cordyceps militaris: The Involvement of Oxidative Changes

Table 5

Hematological values and biochemical parameters of rats treated with CCM for 28 days.

Item	Treatment (g/kg)
	0	1	2	3
Male rats
WBC (×10^9/L)	7.1±1.5	6.9±1.6	6.3±1.1	6.9±1.7
RBC (×10^12/L)	7.1±1.3	7.3±1.2	7.3±1.4	7.3±1.4
Hemoglobin (g/L)	149.2±15.1	148.3±15.2	147.4±19.1	147.5±16.3
Lymphocyte (%)	78.8±11.9	78.5±12.5	76.8±13.5	78.9±12.5
Neutrophil (%)	13.4±3.6	14.1±3.5	15.3±7.0	14.9±3.9
Monocyte (%)	6.7±2.3	6.2±1.5	6.8±2.0	6.6±2.5
Eosinophil (%)	0.7±0.4	0.8±0.4	0.7±0.5	0.8±0.4
Basophil (%)	0.4±0.2	0.4±0.2	0.4±0.2	0.4±0.3
ALT (U/L)	22±3	22±3	27±5^∗	29±5^∗∗
AST (U/L)	97±8	109±23	125±13^∗∗	129±15^∗∗
Totol protein (g/L)	52.1±3.3	52.3±4.6	52.4±3.8	55.1±3.7
Albumin (g/L)	30.0±0.9	30.0±1.3	30.5±0.9	30.1±0.8
BUN (mg/dL)	11.9±2.2	12.2±2.1	12.1±3.3	12.5±4.6
Creatinine (mg/dL)	0.55±0.11	0.54±0.16	0.56±0.17	0.54±0.15
TC (mmol/L)	1.79±0.30	1.66±0.20	1.56±0.17	1.43±0.29^∗
Triglyceride (mmol/L)	0.72±0.33	0.65±0.19	0.50±0.07	0.52±0.17
Glucose (mmol/L)	6.02±0.40	6.09±0.89	5.91±0.98	5.93±0.78
Na (mmol/L)	137±1	138±1	138±2	139±2
K (mmol/L)	5.10±0.65	5.22±0.56	5.15±0.78	5.14±0.54
Cl (mmol/L)	98±1	97±1	97±2	98±3
Female rats
WBC (×10^9/L)	7.5±1.4	5.9±1.1	6.0±1.1	6.2±1.4
RBC (×10^12/L)	7.4±0.3	7.7±0.4	7.7±0.4	7.5±0.5
Hemoglobin (g/L)	151.2±6.1	153.3±10.4	151.5±6.1	150.4±6.2
Lymphocyte (%)	79.1±14.0	77.5±11.2	80.1±14.9	78.8±13.7
Neutrophil (%)	13.9±3.5	14.0±5.7	13.3±4.9	13.3±3.5
Monocyte (%)	5.7±1.7	7.6±3.3	5.9±1.4	6.8±2.8
Eosinophil (%)	0.8±0.7	0.5±0.5	0.4±0.4	0.8±0.5
Basophil (%)	0.4±0.2	0.3±0.2	0.3±0.2	0.4±0.2
ALT (U/L)	20±3	22±3	25±4^∗	28±4^∗∗
AST (U/L)	92±9	98±11	112±14^∗∗	126±12^∗∗
Totol protein (g/L)	56.0±4.6	56.9±2.8	56.8±2.1	53.0±1.9
Albumin (g/L)	34.4±2.5	33.2±1.5	33.1±0.9	30.6±0.9
BUN (mg/dL)	12.5±2.1	12.8±3.4	13.6±3.9	13.2±3.1
Creatinine (mg/dL)	0.57±0.05	0.60±0.11	0.63±0.09	0.60±0.11
TC (mmol/L)	1.97±0.23	1.77±0.26	1.89±0.32	1.56±0.21^∗
Triglyceride (mmol/L)	0.67±0.37	0.59±0.36	0.42±0.12	0.50±0.25
Glucose (mmol/L)	5.98±0.99	5.88±1.00	5.72±0.70	5.80±0.87
Na (mmol/L)	143±1	142±2	143±1	139±1
K (mmol/L)	5.65±0.72	5.63±0.83	5.62±0.51	5.60±0.49
Cl (mmol/L)	100±2	98±2	98±2	96±2

Each value is expressed as mean ± SD (𝑛=10/sex/dose). RBC: red blood cell count; WBC: white blood cell count; AST: aspartate aminotransferase; ALT: alanine aminotransferase; BUN: blood urea nitrogen; TC: total cholesterol; Cl: chloride; Na: sodium; K: potassium.
^∗𝑃<0.05;  ^∗∗𝑃<0.01.