Predicting In Silico Which Mixtures of the Natural Products of Plants Might Most Effectively Kill Human Leukemia Cells?

Figure 1

Subnetwork dysregulated in AML versus normal white blood cells. Interaction-type annotations from KEGG were shown as the letters above the arrows where; E was enzymatic; T was transcription with subscript + showing activation and − showing inhibition; B was protein-to-protein binding. Subscripts for the predicted protein-to-protein interactions were c: for compound interactions, +: activation, −: inhibition, i: an indirect effect, s: a state change, p+: phosphorylation, p−: dephosphorylation, m: methylation, u: ubiquitination, g: glycosylation and “none” for missing information.