Xuebijing Protects Rats from Sepsis Challenged with Acinetobacter baumannii by Promoting Annexin A1 Expression and Inhibiting Proinflammatory Cytokines Secretion
Figure 5
Representative sections showing immunohistochemical expression of annexin A1 in lung tissues from rats in the (a) and (b) normal-control, (c)–(e) sepsis-control, and (f)–(h) sepsis + XBJ groups at 6 (c) and (f), 12 (d) and (g), and 24 (e) and (h) hours after injection, respectively. annexin A1 staining was very limited in control lung, and an improved immunoreactivity could be seen, mainly localized to the cytoplasm of infiltrated neutrophils and hyperplastic alveolar epithelial cells where exudate and fibroplastic proliferation were obviously observed in sepsis-control groups. Notable observation was a more intensely positive reaction for annexin A1 in sepsis + XBJ groups than that of sepsis-control groups, although the number of inflammatory cells was significantly reduced by XBJ administration. Original magnification: (a) ×100 and (b)–(h) ×400.
