Table 1: Chalcones and the corresponding cell lines inhibited by them.

ChalconesCell linesReference

Butein (1)HSC-2, HSC-3, HSG, HL-60[4]
Flavokawain B (2)T24, KB, HCT116[5]
Flavokawain C (17)T24, PANC-1[6, 7]
Pinostrobin chalcone (3)KB, MCF7, Caski, MRC5[5]
2′,4′-dihydroxy-3,4-dimethoxychalcone (4),
2′,4′-dihydroxy-2,3-dimethoxychalcone (5),
2′,4′-dihydroxy-4-methoxychalcone (6)
HL-60, SMMC-7721[8]
2′,4′-dihydroxy-3′,5′-dimethyl-6′-methoxychalcone (7)SMMC-7721, 8898, HeLa, SPC-A-1, 95-D, GBC-SD, MCF-7, SKBR-3, SW-480[9, 10]
Stercurensin (8)SW-480[11]
Cardamonin (9)SW-480, PANC-1[11]
2′,4′-dihydroxychalcone (10)26-L5, B16-BL6, LLC, A549, HeLa, HT-1080[12]
4,4′-dihydroxy-2′-methoxychalcone (11)26-L5, B16-BL6, LLC, A549, HeLa, HT-1080, SH-SY5Y[12, 13]
Isoliquiritigenin (12)26-L5, B16-BL6, LLC, A549, HeLa, HT-1080[12, 14]
3′,4,4′-trihydroxy-2,6-dimethoxychalcone (15),
3′,6-dihydroxy-2,4,4′-trimethoxy-3-(3′′,4′′-dihydroxybenzyl)chalcone (95)
MCF-7/ADR, BEL-7402/5-FU[15]
3′-formyl-2′,4′-dihydroxy-6′-methoxychalcone (20)KB, MCF-7[16]
Abyssinone A (50), B (51), C (52), D (27)Caco2[17]
5′′-(2′′′-hydroxyisopropyl-)-dihydrofurano-[2′′,3′′-B]-4,4′-dihydroxy-6′-methoxychalcone (67)BGC-823[18]
Flavokawin (13),
3′-geranylchalconaringenin (29),
5′-prenylxanthohumol (30),
xanthohumol H (31), xanthogalenol (33),
4-methylxanthohumol (34),
xanthohumol C (53),
1′′,2′′-dihydroxanthohumol C (55)
HeLa[19]
Desmethylxanthohumol (32)HeLa, DU145, PC-3[20, 21]
Licochalcone A (35), C (36), E (37)HT-1080[14]
2′,4′,2,4-tetrahydroxy-3′-prenyl-6′-methoxychalcone (38)HL-60, L1210, U937[22]
Cyclokuraridin (58)KB[23]
3-hydroxy-4-methoxylonchocarpin (60)A2780, B16, K562, LL/2, 7860, HeLa[24]
4-methoxylonchocarpin (61)HeLa, K562, LL/2, 7860, A2780, B16[24]
Isobavachromene (62)7860, A549, A2780, B16, HeLa, K562, LL2[24]
Millepachine (66)HepG2, C26, LL2, B16[25]
5′-geranyl-2′,4′,4-trihydroxychalcone (39)SW 872, HT-29, Hep3B, PLC5, Huh7, HepG2, COLO205[26]
Isocordoin (40)P388[27]
Derricin (41),
lonchocarpin (59)
CEM[28]
Isobavachalcone (42)HT-1080, MCF-7, MCF-7/ADR[29]
4-hydroxyderricin (47)KATO III[30]
Xanthoangelol (44)SW 872, HT-29, COLO205, Hep3B, PLC5, Huh7, HepG2, KATO III[26, 30]
Isolespeol (68)HT-29, COLO205, Hep3B, PLC5, Huh7[26]
2′,4′-dihydroxy-3′-(1′′-geranyl)-6′-methoxychalcone (28), (−)-nicolaioidesin B (71),
(±)-isopanduratin A1 (72),
(1′R,2′S,6′R)-2-hydroxyisopanduratin A (73),
panduratin A (74), (−)-isopanduratin A2 (75),
(−)-hydroxypanduratin A (76),
(±)-panduratin C (77),
(±)-6-methoxypanduratin A (78),
PANC-1[7]
Australisine A (85)HCT-8, A2780[31]
Australisine B (79), mulberrofurans E (80), F (81), mongolicin C (83), chalcomoracin (84)A549, Bel7402, BGC-823, HCT-8, A2780[31]
Mulberrofuran G (82)A549, BGC-823, HCT-8, A2780[31]
Australisine C (86)A2780[31]
Yunanensin A (87)A549, Bel7402, BGC-823, HCT-8, A2780[32]
Japonicone A (94)HeLa, Bel7402, MCF-7/ADR, Bel7402/5-FU[33]
3′,6-dihydroxy-2,4,4′-trimethoxy-3-(3′′,4′′-dihydroxybenzyl)chalcone (95)MCF-7/ADR, BEL-7402/5-FU[15]
2′,4′-dihydroxy-3′-(2-hydroxybenzyl)-6′-methoxychalcone (96)KB, BC[34]
Rhuschalcones I (23), II (24), III (25), V (97), VI (98) HT-29, HCT-116[35]
Rhuschalcone IV (26)HT-29, HCT-116, SK-MEL-5, SK-MEL-28, UACC-62[35]
Xanthohumol (49)DU145, PC-3, HeLa, MCF-7/ADR, HT-1080[1921, 29]