Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition

Table 1

Renal function in the membranous glomerulonephritis model rats after treatment with the skimmin for 30 days.

Index	Sham control	Model control	Groups
			MMF (20 mg/kg)	Skimmin (15 mg/kg)	Skimmin (30 mg/kg)
𝑁	10	10	10	10	10
Body weight (g)	311.25±18.15	293.65±28.46	287.00±28.79	284.50±28.79	281.70±20.00
Urine creatinine (mM)	4.34±1.58	2.87±1.17^∗	3.02±1.74	3.00±1.51	4.35±1.10^#
Blood urea nitrogen (mM)	7.53±1.40	21.08±17.30^∗	16.21±10.13	22.25±11.80	12.08±10.09^#
Serum creatinine (mM)	0.16±0.10	1.22±1.31^∗	0.98±1.17	1.24±0.91	0.54±0.87^#
Creatinine clearance (mL/min)	2.57±0.01	1.43±0.03^∗	1.26±0.02	0.75±0.05	2.40±0.07^#
Urinary albumin excretion (mg/day)	0.22±0.15	5.64±3.01^∗∗	3.93±2.23^#	4.88±2.96^##	3.61±2.14^##

^∗𝑃<0.05, ^∗∗𝑃<0.01, versus normal control; ^#𝑃<0.05, ^##𝑃<0.01, versus model control, by One-Way-ANOVA followed by post hoc test.