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Evidence-Based Complementary and Alternative Medicine
Volume 2013, Article ID 820695, 11 pages
http://dx.doi.org/10.1155/2013/820695
Research Article

The Cardioprotective Effects of Citric Acid and L-Malic Acid on Myocardial Ischemia/Reperfusion Injury

1Experimental Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
2Key Laboratory of Modern Preparation of TCM, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
3Beijing University of Chinese Medicine, Beijing 100029, China

Received 26 December 2012; Revised 3 April 2013; Accepted 4 April 2013

Academic Editor: Hao Xu

Copyright © 2013 Xilan Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. T. Turer and J. A. Hill, “Pathogenesis of myocardial ischemia-reperfusion injury and rationale for therapy,” The American Journal of Cardiology, vol. 106, no. 3, pp. 360–368, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. National Pharmacopoeia Committee, Chinese Pharmacopoeia, vol. 1, Chemical Industry Press, Beijing, China, 2005.
  3. J. Ao, H. Feng, and F. Xia, “Transforming growth factor and nuclear factor kappa B mediated prophylactic cardioprotection by total flavonoids of fructus chorspondiatis in myocardial ischemia,” Cardiovascular Drugs and Therapy, vol. 21, no. 4, pp. 235–241, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. G. L. Qu, “The study on pharmacodynamic material basis of Fructus Choerospondiatis and Radix et Rhizoma Rhodiolae Crenulatae,” Postdoctoral Research Report, The Chinese Academy of Traditional Chinese Medicine, 2012. View at Google Scholar
  5. X. G. Liu and Y. S. Chen, “Component analysis of of fructus chorspondiatis,” Chinese Wild Plant Resources, vol. 19, no. 3, pp. 35–40, 2000 (Chinese). View at Google Scholar
  6. K. K. Dharmappa, R. V. Kumar, A. Nataraju, R. Mohamed, H. V. Shivaprasad, and B. S. Vishwanath, “Anti-inflammatory activity of oleanolic acid by inhibition of secretory phospholipase A2,” Planta Medica, vol. 75, no. 3, pp. 211–215, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. K. Takada, T. Nakane, K. Masuda, and H. Ishii, “Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-α-induced E-selectin expression by cultured umbilical vein endothelial cells,” Phytomedicine, vol. 17, no. 14, pp. 1114–1119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. K. Y. Kim, K. M. Lim, J. Y. Noh et al., “Novel antiplatelet activity of protocatechuic acid through the inhibition of high shear stress-induced platelet aggregation,” Journal of Pharmacology and Experimental Therapeutics, vol. 343, no. 3, pp. 704–711, 2012. View at Publisher · View at Google Scholar
  9. X. Wang, X. L. Ye, R. Liu et al., “Antioxidant activities of oleanolic acid in vitro: possible role of Nrf2 and MAP kinases,” Chemico-Biological Interactions, vol. 184, no. 3, pp. 328–337, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. R. Varì, M. D'Archivio, C. Filesi et al., “Protocatechuic acid induces antioxidant/detoxifying enzyme expression through JNK-mediated Nrf2 activation in murine macrophages,” Journal of Nutritional Biochemistry, vol. 22, no. 5, pp. 409–417, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. Z. Wang, M. Li, W. K. Wu, H. M. Tan, and D. F. Geng, “Ginsenoside Rb1 preconditioning protects against myocardial infarction after regional ischemia and reperfusion by activation of phosphatidylinositol-3- kinase signal transduction,” Cardiovascular Drugs and Therapy, vol. 22, no. 6, pp. 443–452, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. J. X. Liu, X. Z. Li, X. B. Ma et al., “Cardio-protective effects of Corocalm on acute myocardial ischemia/reperfusion injury in rats,” Chinese Journal of Integrative Medicine, vol. 12, no. 3, pp. 199–202, 2006. View at Google Scholar · View at Scopus
  13. G. V. Born and M. J. Cross, “The aggregation of blood platelets,” The Journal of Physiology, vol. 168, pp. 178–195, 1963. View at Google Scholar · View at Scopus
  14. X. O. Wang, S. Ma, and G. X. Qi, “Effect of hypoxia-inducible factor 1-alpha on hypoxia/reoxygenation-induced apoptosis in primary neonatal rat cardiomyocytes,” Biochemical and Biophysical Research Communications, vol. 417, no. 4, pp. 1227–1234, 2012. View at Publisher · View at Google Scholar
  15. P. Li, J. H. Fu, J. K. Wang, J. G. Ren, and J. X. Liu, “Extract of paris polyphylla simth protects cardiomyocytes from anoxia-reoxia injury through inhibition of calcium overload,” Chinese Journal of Integrative Medicine, vol. 17, no. 4, pp. 283–289, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. J. Zhang, A. Liu, R. Hou et al., “Salidroside protects cardiomyocyte against hypoxia-induced death: a HIF-1α-activated and VEGF-mediated pathway,” European Journal of Pharmacology, vol. 607, no. 1–3, pp. 6–14, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. H. J. Pan, D. Y. Li, F. Fang et al., “Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury,” Journal of Cardiovascular Pharmacology, vol. 58, no. 5, pp. 535–542, 2011. View at Publisher · View at Google Scholar
  18. M. P. Wymann, M. Zvelebil, and M. Laffargue, “Phosphoinositide 3-kinase signalling—which way to target?” Trends in Pharmacological Sciences, vol. 24, no. 7, pp. 366–376, 2003. View at Publisher · View at Google Scholar · View at Scopus
  19. Y. C. Li, C. H. Yeh, M. L. Yang, and Y. H. Kuan, “Luteolin suppresses inflammatory mediator expression by blocking the Akt/NFκB pathway in acute lung injury induced by lipopolysaccharide in mice,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, Article ID 383608, 8 pages, 2012. View at Publisher · View at Google Scholar
  20. N. Robinson, “Integrative medicine-traditional Chinese medicine, a model?” Chinese Journal of Integrative Medicine, vol. 17, no. 1, pp. 21–25, 2011. View at Publisher · View at Google Scholar
  21. H. Xu and K. Chen, “Complementary and alternative medicine: is it possible to be mainstream?” Chinese Journal of Integrative Medicine, vol. 18, no. 6, pp. 403–404, 2012. View at Publisher · View at Google Scholar
  22. G. Dobos and I. Tao, “The model of western Integrative medicine: the role of Chinese medicine,” Chinese Journal of Integrative Medicine, vol. 17, no. 1, pp. 11–20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  23. X. L. Tang, J. X. Liu, L. Li et al., “Cardioprotective effects of total organic acids in Fructus Choerospondiatis on myocardial ischemia-reperfusion injury,” Chinese Journal of Experimental Traditional Medical Formulae, vol. 19, no. 4, pp. 168–172, 2013 (Chinese). View at Google Scholar
  24. X. L. Tang, J. X. Liu, P. Li et al., “Protective effects of kaempferol and quercetin on hypoxia/reoxygenation and peroxidation injury in neonatal cardiomyocytes,” Pharmacology and Clinics of Chinese Materia Medica, vol. 18, no. 5, pp. 243–246, 2012 (Chinese). View at Google Scholar
  25. J. Hallén, “Troponin for the estimation of infarct size: what have we learned?” Cardiology, vol. 121, no. 3, pp. 204–212, 2012. View at Publisher · View at Google Scholar
  26. M. Akhlaghi and B. Bandy, “Mechanisms of flavonoid protection against myocardial ischemia-reperfusion injury,” Journal of Molecular and Cellular Cardiology, vol. 46, no. 3, pp. 309–317, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. J. Vinten-Johansen, R. Jiang, J. G. Reeves, J. Mykytenko, J. Deneve, and L. J. Jobe, “Inflammation, proinflammatory mediators and myocardial ischemia-reperfusion injury,” Hematology/Oncology Clinics of North America, vol. 21, no. 1, pp. 123–145, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Kleinbongard, G. Heusch, and R. Schulz, “TNFα in atherosclerosis, myocardial ischemia/reperfusion and heart failure,” Pharmacology and Therapeutics, vol. 127, no. 3, pp. 295–314, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. N. G. Frangogiannis, C. W. Smith, and M. L. Entman, “The inflammatory response in myocardial infarction,” Cardiovascular Research, vol. 53, no. 1, pp. 31–47, 2002. View at Publisher · View at Google Scholar · View at Scopus
  30. Y. Xu, Y. Huo, M. C. Toufektsian et al., “Activated platelets contribute importantly to myocardial reperfusion injury,” American Journal of Physiology—Heart and Circulatory Physiology, vol. 290, no. 2, pp. H692–H699, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. M. I. Oerlemans, S. Koudstaal, S. A. Chamuleau, D. P. de Kleijn, P. A. Doevendans, and J. P. Sluijter, “Targeting cell death in the reperfused heart: pharmacological approaches for cardioprotection,” International Journal of Cardiology, vol. 165, no. 3, pp. 410–422, 2013. View at Publisher · View at Google Scholar
  32. Y. Fujio, T. Nguyen, D. Wencker, R. N. Kitsis, and K. Walsh, “Akt promotes survival of cardiomyocytes in vitro and protects against lschemia-reperfusion injury in mouse heart,” Circulation, vol. 101, no. 6, pp. 660–667, 2000. View at Google Scholar · View at Scopus
  33. A. Hamacher-Brady, N. R. Brady, and R. A. Gottlieb, “The interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy,” Cardiovascular Drugs and Therapy, vol. 20, no. 6, pp. 445–462, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. L. Parhamifar, H. Andersen, S. M. Moghimi et al., “Lactate dehydrogenase assay for assessment of polycation cytotoxicity,” Methods in Molecular Biology, vol. 948, pp. 13–22, 2013. View at Google Scholar
  35. S. A. Lakhani, A. Masud, K. Kuida et al., “Caspases 3 and 7: key mediators of mitochondrial events of apoptosis,” Science, vol. 311, no. 5762, pp. 847–851, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. L. Ji, F. Fu, L. Zhang et al., “Insulin attenuates myocardial ischemia/reperfusion injury via reducing oxidative/nitrative stress,” American Journal of Physiology—Endocrinology and Metabolism, vol. 298, no. 4, pp. E871–E880, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. T. Matsui, J. Tao, F. del Monte et al., “Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo,” Circulation, vol. 104, no. 3, pp. 330–335, 2001. View at Google Scholar · View at Scopus