Table 1: Characteristics of the patients and the baseline adequate relief*, bowel function scores**, symptom scores**, and IBS quality of life scores**.

VariablesGJS+DUO 
( )
GJS+DUO-P 
( )
GJS-P+DUO 
( )
GJS-P+DUO-P
( )
value

Mean age (SD)49.6 (14.3)47.5 (13.6)47.1 (10.5)47.5 (16.0)0.959
Mean BMI (SD)22.8 (3.6)22.3 (3.8)22.9 (3.0)23.3 (3.2)0.684
Male (%)73.362.550.076.50.415
Smoking (%)20.025.018.817.60.974
Drinking (%)80.056.362.552.90.423
Adequate relief (%)15.425.013.30.00.243
Bowel function score
 Frequency15.54 (8.60)13.64 (7.07)15.00 (7.08)12.23 (5.42)0.646
 Consistency1.66 (1.02)0.87 (0.61)1.13 (0.76)1.31 (0.91)0.079
 Ease of passage1.04 (1.09)1.19 (0.74)1.30 (0.80)1.21 (0.69)0.326
Symptom score (mm)
 Abdominal pain38.49 (20.40)31.04 (17.73)40.48 (17.60)32.37 (22.24)0.554
 Abdominal discomfort39.65 (20.17)34.82 (19.72)43.87 (17.54)36.82 (17.44)0.638
 Bloating39.11 (21.20)30.12 (17.25)40.35 (19.95)35.47 (20.95)0.554
 Flatulence36.04 (16.72)27.41 (15.63)38.57 (17.07)32.96 (20.51)0.400
 Urgency38.97 (18.34)34.58 (18.73)44.33 (14.59)38.44 (13.62)0.507
 Mucus in stool36.65 (20.83)26.43 (18.28)37.50 (17.77)35.31 (19.64)0.416
 Overall symptom46.90 (23.24)36.77 (18.24)51.08 (12.98)43.40 (14.15)0.209
Overall IBS quality of life52.00 (29.14)42.21 (22.49)54.92 (24.78)41.00 (18.26)0.366

GJS: Gwakhyangjeonggisan, DUO: Duolac7S, GJS-P: placebo of Gwakhyangjeonggisan, DUO-P: placebo of Duolac7S.
Baseline values were analyzed by Fisher’s exact test for categorical variables and one-way ANOVA for continuous variables.
*Adequate relief is presented as the percentage of the number answering “yes” to AR question/total number.
**Bowel function, symptom, and IBS quality of life scores are presented as mean (standard deviation).
Used a scale of 1–7: 1, watery stool; 7, hard, lumpy stool (based on Bristol stool form scale).
Used a scale of 1–7: 1, fecal incontinence; 7, manual disimpaction.