Nymphaeol-A Isolated from Okinawan Propolis Suppresses Angiogenesis and Induces Caspase-Dependent Apoptosis via Inactivation of Survival Signals
Figure 8
z-VAD-fmk reverses apoptosis induction by nymphaeol-A. HUVECs were treated with nymphaeol-A at the indicated concentrations and 10 μM z-VAD-fmk, a pan-caspase inhibitor, for 12 h. Caspase-3/7 activity was measured using the Caspase-Glo Assay Kit by luminescence assays as described in the text. *, as compared with the control group.